Experimental pulmonary hypertension in the dog

Effects of pulmonary gas embolism on circulation and respiration in the dog

“…The second part of this review is devoted to the lung passage of gas bubbles. Mandelbaum and King (1963) reported that they macroscopically saw bubbles in the lung veins in 3 out of 5 experimental animals (dogs) 10 to 30 min after venous injection of 1.5 ml kg N2- Deal et al (1971) Gilbert et al (1968), and Wright (1962) found no signs of arterial embolism after repeated injection of various amounts of air, oxygen or helium in rabbits and dogs.…”

“…The great difference, however, is the reversible character of the anatomical changes after stopping the gas injections (Boerema, 1962;Gilbert et al, 1968;Wright, 1962 hardly affected the uptake of oxygen. The most important origin of the disturbed gas exchange in pulmonary gas embolism seemed to be an increased inequality of the ventilation-perfusion ratio distribution.…”

“…A) a rapid increase in pulmonary arterial pressure (P aD ) reaching a maximum within 30 to 60 s after the gas injection, followed by a slow decrease to the original level within 10 to 15 min; B) a small short-lasting decrease of cardiac output (Q) and systemic arterial pressure (P a ) with a synchronous small rise of central venous pressure; C) an unchanged pulmonary wedge pressure and left atrial pressure (Berglund and Josephson, 1970;Cockett et al, 1968;Deal et al, 1971;Gilbert et al, 1968;Josephson, 1970a, 1970b, Mandelbaum and King, 1963.…”