Experimental Psychoses Induced by Benactyzine in Alcoholics

Vojtechovsky, M; Krus, David J.; Grof, Stanislav; Vítek, V.; Rysánek, K; Kunz, K; Skála, J

doi:10.1016/s0079-6123(08)64545-8

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C) Miscellaneous Studies1

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1971

1986

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Cited by 4 publications

(2 citation statements)

References 17 publications

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“…Thus, activities midway between inactivity and the reported activity (i.e., 0.5 and 2.5 mescaline units, respectively) were assumed for these compounds. Although I1 has an activity of less than 1 mescaline unit, one study (6) reported an activity of 0.2 mescaline unit, and this latter value was used in the regression analysis.…”

Section: Methodsmentioning

confidence: 99%

Molecular Connectivity Analysis of Hallucinogenic Mescaline Analogs

Glennon

Kier

Shulgin³

1979

Journal of Pharmaceutical Sciences

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Section: Methodsmentioning

confidence: 99%

Molecular Connectivity Analysis of Hallucinogenic Mescaline Analogs

Glennon

Kier

Shulgin³

1979

Journal of Pharmaceutical Sciences

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“…Eight studies (5,8,16,23,31,39,46,47) of LSD in alcoholic patients do not fit the categories discussed above. These findings are of great heuristic value, however, and therefore will be individually discussed without an attempt at tabulation since they are heterogeneous in methodology and results.…”

Section: C) Miscellaneous Studiesmentioning

confidence: 99%

A Review of LSD Treatment in Alcoholism

Fs¹,

Anderson

1971

Int Pharmacopsychiatry

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A total of 31 investigations involving 1,105 patients, on the effect of LSD in the treatment of alcoholics are reviewed. There were 13 single large-dose studies without controls, 5 such studies with controls, 4 studies of multiple low-dose LSD without controls, 3 multiple low-dose studies with controls, and 6 miscellaneous investigations that did not fit any of these categories. Single doses ranged between 50 and 800 μg, while multiple doses ranged (per single dose) from 25 to 800 μg, with a total maximum dose of 100-6,400 μg (maximum of 6 doses). Follow-up ranged from none to 65 months. The overall effectiveness of this controversial treatment of alcoholics remains disappointing. It was difficult to reach meaningful generalizations from the variety of published investigations with different designs and variant criteria for improvement.

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