Experimental Pseudomonas aeruginosa Keratitis From Extended Wear of Soft Contact Lenses

Koch, Jörg; Refojo, Miguel F.; Hanninen, Laila A.; Leong, Fee‐Lai; Kenyon, Kenneth R.

doi:10.1001/archopht.1990.01070120101038

Cited by 14 publications

(6 citation statements)

References 28 publications

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“…Other modes of inoculation to produce keratitis by P. aeruginosa include topical inoculation preceded by corneal scratch [43–45], corneal abrasion [46], and mechanical removal of the corneal epithelium [42]. Pseudomonas -contaminated contact lenses have also been used in rabbits [47–51]. …”

Section: Rabbits and Pseudomonas Aeruginosamentioning

confidence: 99%

Animal Models of Bacterial Keratitis

Marquart

2011

BioMed Research International

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Bacterial keratitis is a disease of the cornea characterized by pain, redness, inflammation, and opacity. Common causes of this disease are Pseudomonas aeruginosa and Staphylococcus aureus. Animal models of keratitis have been used to elucidate both the bacterial factors and the host inflammatory response involved in the disease. Reviewed herein are animal models of bacterial keratitis and some of the key findings in the last several decades.

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Section: Rabbits and Pseudomonas Aeruginosamentioning

confidence: 99%

Animal Models of Bacterial Keratitis

Marquart

2011

BioMed Research International

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“…Infection does not occur in adult mice without damage to the cornea (Lawin-Brussel et al, 1990, 1993Koch et al, 1990). Severe infection normally develops within 12-24 hr and keratitis follows, characterised by corneal opacity with extensive infiltration of PMNs (Berk, Lean and Hazlett, 1979).…”

Section: Introductionmentioning

confidence: 99%

An Ocular Strain ofPseudomonas aeruginosais Inflammatory but not Virulent in the Scarified Mouse Model

Cowell

Willcox

Hobden

et al. 1998

Experimental Eye Research

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“…adenovirus [43], or HSV-1 [117,137]), or bacteria e.g. Staphylococcus [40] and Pseudomonas [62]. Furthermore, the infiltration of polymorphonuclear cells (PMNs) into Pseudomonas-infected eye corresponded with tissue damage, as observed by electron microscopy [62].…”

Section: Leukocyte Infiltration Is Associated With the Progression Ofmentioning

confidence: 99%

Leukocyte-endothelial interactions within the ocular microcirculation in inflammation and infection

Al-Banna

Toguri

Kelly

et al. 2013

Clinical Hemorheology and Microcirculation

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Leukocyte-endothelial interactions within the microvasculature represent a hallmark of inflammation regardless of whether the inflammation results from non-infectious or infectious triggers. In this review, we highlight features of leukocyte recruitment in ocular disease and postulate mechanisms by which the infiltrating cells may lead to the progression of the ocular inflammatory response, including cytokine and chemokine production, T cell or non-T cell responses. Additionally, ex-vivo and in vivo methods used to study the general features of the immune response are discussed, with a specific focus on intravital imaging, which allows real-time non-invasive examination of leukocyte-endothelial interactions in the ocular microvasculature. At the present time there are still significant gaps in our understanding of the process of leukocyte recruitment in vivo in different microvascular beds. Further studies using non-invasive imaging approaches, such as intravital microscopy, provide an opportunity to study dynamic tissue-specific leukocyte-endothelial interactions in vivo and identify novel targets for early intervention in the inflammatory process. This knowledge is essential to the rational use of therapeutics to resolve inflammation in ocular disease.

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Experimental Pseudomonas aeruginosa Keratitis From Extended Wear of Soft Contact Lenses

Cited by 14 publications

References 28 publications

Animal Models of Bacterial Keratitis

Animal Models of Bacterial Keratitis

An Ocular Strain ofPseudomonas aeruginosais Inflammatory but not Virulent in the Scarified Mouse Model

Leukocyte-endothelial interactions within the ocular microcirculation in inflammation and infection

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