Experimental provocation of ‘ice-cream headache’ by ice cubes and ice water

Mages, Stephan; Hensel, O.; Zierz, Antonia Maria; Kraya, Torsten; Zierz, Stephan

doi:10.1177/0333102416650704

Cited by 16 publications

(18 citation statements)

References 12 publications

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“…The most frequent sites of HICS found by this study were to those previously described (3,4,7,9,10,13,21,22). Thus, temporal and frontal localizations can be regarded as typical sites for the occurrence of HICS.…”

Section: Discussionsupporting

confidence: 83%

“…It is most likely caused by eating ice cream, drinking slush ice drinks, or inhaling very cold gases and is characterized by a short-lasting pain sensation in the frontal or temporal region, which may be of high intensity (1). There are some studies that examine HICS in an experimental setting, in which HICS is provoked by either eating ice cream, drinking cold water or keeping an ice cube pressed to the palate (2–10). Fewer studies explore the characteristics of HICS using questionnaires (5,11–15).…”

Section: Introductionmentioning

confidence: 99%

“…In the past, subjects for experimental studies were mainly recruited from a group of participants who suffered from another primary headache disorder (3,7). More recent experimental studies used randomly recruited volunteers (9,10).…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and characteristics of headache attributed to ingestion or inhalation of a cold stimulus (HICS): A cross-sectional study

et al. 2019

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Background Headache attributed to ingestion or inhalation of a cold stimulus (HICS), colloquially called ice-cream headache, is a common form of a primary headache in adults and children. However, previous studies on adults are limited due to the small number of patients. Furthermore, most of the subjects in previous studies had a history of other primary headaches. Methods Biographic data, clinical criteria of HICS and prevalence of primary headache were collected by a standardized questionnaire. A total of 1213 questionnaires were distributed; the return rate was 51.9% (n = 629); 618 questionnaires could be analyzed. Results In a cohort of 618 people aged between 17–63 years (females: n = 426, 68.9%), the prevalence of HICS was 51.3% (317 out of 618). There was no difference between men and women (51.3% vs. 51.6%). The duration of HICS was shorter than 30 sec in 92.7%. In the HICS group, localization of the pain was occipital in 17%. Trigemino-autonomic symptoms occurred in 22%, and visual phenomena (e.g. flickering lights, spots or lines) were reported by 18% of the HICS group. The pain intensity, but not the prevalence of HICS, was higher when tension-type headache and migraine or both were present as co-morbid primary headaches (Numeric Rating Scale (NRS) 4.58 and 6.54, p = 0.006). There was no higher risk of participants with migraine getting HICS than for those who did not have migraine (odds ratio = 1.17, 95% confidence interval (CI) 0.75–1.83; p = 0.496). Conclusion The results of this study modified the current criteria for HICS in the ICHD-3 regarding duration and localization. In addition, accompanying symptoms in about one fifth of the participants are not mentioned in the ICHD-3. Neither migraine nor tension-type headache seems to be a risk factor for HICS. However, accompanying symptoms in HICS are more frequent in subjects with another primary headache than in those without such a headache.

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

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Prevalence and characteristics of headache attributed to ingestion or inhalation of a cold stimulus (HICS): A cross-sectional study

et al. 2019

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“…A relative dose is yet to be administered to athletes, but an experimental dose of 30 mg/kg was prescribed by food scientists investigating the effects of carbonation and menthol upon oral cooling [85]. Partnering menthol's chemosensory cooling effects with physiological coolants, such as ice slurries may further enhance its efficacy [86,87,88], but there is an increased risk of overstimulation of the trigeminal system potentially resulting in "brain freeze" [89,90,91].…”

Section: Mentholmentioning

confidence: 99%

Can taste be ergogenic?

et al. 2020

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Taste is a homeostatic function that conveys valuable information, such as energy density, readiness to eat, or toxicity of foodstuffs. Taste is not limited to the oral cavity but affects multiple physiological systems. In this review, we outline the ergogenic potential of substances that impart bitter, sweet, hot and cold tastes administered prior to and during exercise performance and whether the ergogenic benefits of taste are attributable to the placebo effect. Carbohydrate mouth rinsing seemingly improves endurance performance, along with a potentially ergogenic effect of oral exposure to both bitter tastants and caffeine although subsequent ingestion of bitter mouth rinses is likely required to enhance performance. Hot and cold tastes may prove beneficial in circumstances where athletes' thermal state may be challenged. Efficacy is not limited to taste, but extends to the stimulation of targeted receptors in the oral cavity and throughout the digestive tract, relaying signals pertaining to energy availability and temperature to appropriate neural centres. Dose, frequency and timing of tastant application likely require personalisation to be most effective, and can be enhanced or confounded by factors that relate to the placebo effect,

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“…In 10 of 39 (26%) after the first HICS (HICS resolved completely) a second headache occurred with a latency of 12 s (range 3–26 s). This and other clinical details of the experiment have been published elsewhere (7). At the end of ice water ingestion, the MFV in both MCAs had increased compared to luke-warm water stimulus (7.0 ± 10.2%, p < 0.001).…”

Section: Resultsmentioning

confidence: 99%

Increased Blood Flow Velocity in Middle Cerebral Artery and Headache Upon Ingestion of Ice Water

et al. 2019

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Introduction: “Headache attributed to ingestion or inhalation of a cold stimulus” (HICS) is one of the most common primary headache disorders. Little is known about the pathophysiology of HICS and other headache disorders. The aim of this study was to analyze mean flow velocity (MFV) and cerebrovascular resistance (RI) in both middle cerebral arteries (MCA) upon ingestion of ice water. Methods: The MFV and RI in both MCAs was continuously measured by transcranial sonography. HICS was induced by drinking 200 ml of ice water. Results: In all volunteers, the ingestion of ice water led to a decrease in RI, which was accompanied by an increase in MFV. In volunteers with induced HICS, MFV were significantly higher compared to volunteers that did not experience HICS. In volunteers with HICS, MFV increased even more significantly when lacrimation occurred compared to volunteers in which it did not. In volunteers without induced HICS, MFV was higher in those volunteers with a positive history of HICS than in those with a negative HICS history. Conclusion: This study revealed a raised MFV upon ingestion of ice water. Volunteers with a provoked case of HICS had a higher MFV than volunteers without HICS. The increase in MFV was even higher when the headache was accompanied by lacrimation. This may indicate an involvement of the trigeminal-parasympathetic vasodilator reflex.

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Experimental provocation of ‘ice-cream headache’ by ice cubes and ice water

Cited by 16 publications

References 12 publications

Prevalence and characteristics of headache attributed to ingestion or inhalation of a cold stimulus (HICS): A cross-sectional study

Prevalence and characteristics of headache attributed to ingestion or inhalation of a cold stimulus (HICS): A cross-sectional study

Can taste be ergogenic?

Increased Blood Flow Velocity in Middle Cerebral Artery and Headache Upon Ingestion of Ice Water

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