Experimental production of pigmented villonodular synovitis in the knee and ankle joints of rhesus monkeys

Singh, Ramandeep; Grewal, D. S.; Chakravarti, R. N.

doi:10.1002/path.1710980207

Cited by 47 publications

(23 citation statements)

References 4 publications

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“…Some attempts have been made to induce PVNS experimentally. Lesions have been induced by injecting colloidal iron into the joints of rabbits [32] and by injecting blood, colloidal iron, plasma and gum acacia into the ankles of monkeys [30]. The colloidal iron produced changes similar to PVNS except for the absence of foam cells and very small numbers of giant cells.…”

Section: Discussionmentioning

confidence: 99%

Proliferating cell nuclear antigen labelling index in localised pigmented villo-nodular synovitis and its relationship to the size of nodules

Rosa

Galli

Fadda

et al. 2000

International Orthopaedics

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Proliferating cell nuclear antigen (PCNA) is one of the cell cycle-related proteins directly involved in DNA synthesis. It is a marker of cellular proliferation and has been shown to correlate with ploidy and proliferative activity of cells. Its expression has been used to estimate the growth fraction of human cancer and its prognostic value. Pigmented villo-nodular synovitis (PVNS) is characterised by a nodular lesion in the paratendinous synovial tissue or, less frequently, in a joint. Whether PVNS is a neoplastic or inflammatory lesion remains controversial. We have studied immunohistochemical PCNA expression with pc10 monoclonal antibody in 16 paraffin sections, in 16 cases of localised PVNS, or giant cell tumour of tendon sheath. We have found significant correlation between the size of the lesions and PCNA-LI (labelling index).Résumé L'antigène nucleaire de prolifération cellulaire (PCNA) est une des proteines du cycle cellulaire et il est impliqué directement dans la synthèse du DNA. Il s'agit certainement d'un indicateur de prolifération cellulaire. Son expression a été employé pour évaluer l'index de prolifération de la tumeur humaine et son valeur au point de vue pronostique. La synovite villo-nodulaire pigmentée (PVNS) est caractérisée par une lésion nodulaire plus fréquente dans les localisations tendineuses que dans les articulations. S'il s'agit d'un processus néoplasique ou d'une lésion inflammatoire reste controversée. Nous avons étudiés l'expression immunohistochimique du PCNA avec l'anticorps monoclonal PC10 en 16 lames paraffinés relatives à 16 synovites villo-nodulaires pigmentées localisées ou tumeurs à cellules geantes des gaines tendineuses. Nous avons trouvés une corrélation significative entre les dimensions des lésions nodulaires et le PCNA labelling index (PCNA-LI).

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Section: Discussionmentioning

confidence: 99%

Proliferating cell nuclear antigen labelling index in localised pigmented villo-nodular synovitis and its relationship to the size of nodules

Rosa

Galli

Fadda

et al. 2000

International Orthopaedics

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“…Previously this condition was designated "xanthoma" because of the peculiar reaction of the synovial membrane, later many other terms were used, viz, villous arthritis, hemorrhagic villous synovitis, benign and malignant giant cell tumor, xanthogranuloma, myleoplaxoma and pigmented villonodular synovitis [5]. Introduced the term PVNS in 1941 to describe a yellow tumor-like synovial lesion [12]. The most widely held theory is that the disease is an inflammatory reaction of the synovium [1].…”

Section: Etiologymentioning

confidence: 99%

“…However, some evidence exists that it is a benign neoplastic process [13]. The exact etiology of (PVNS) is not know [12].…”

Section: Etiologymentioning

confidence: 99%

Pigmented Villonodular Synovitis (PVNS) in Human and Animals: A Mini Review Article and Conclusive View

Attar¹,

Azreg²,

Abdouslam³

2017

ICPJL

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“…In the advanced stages, synovial inflammation (pannus) can invade cartilage, bone, capsule with joint destruction [5]. Recurrent synovial hemorrhages are transformed by phagocytes to extra-and intracellular hemosiderin deposits seen on MRI study as "blooming" artefacts (MRI gradient-echo) and on biopsy specimens [6]. Nodular structure of histiocytic infiltrates with multinucleated giant cells, foam cells and dense fibrosis are common histologic findings [7].…”

Section: Introductionmentioning

confidence: 99%

Pigmented Villonodular Synovitis for Combined Therapy

Rozin

2014

J Med Cases

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Pigmented villonodular synovitis (PVNS), inflammatory proliferative disease resulting from synovial cells, has progressive course similar neoplastic local expansion. We followed up a case with effective combined therapy for diffuse PVNS despite incomplete response to its components and reviewed therapies based on MedLine for PVNS. Due to US data residue synovitis after open radical synovectomy, we made decision about external beam radiotherapy. Photon radiation with linear accelerator energy of 6 MV was applied for two fields: anterior and posterior. The total dose was 20 Gy, delivered in 2 Gy a day, five times a week. Due to postoperative pain and the rest of synovial tissue on US study, pharmacologic therapy with salazopyrine and celecoxib was added. For several weeks, the knee pain became episodic and further disappeared. Six months later, the patient feels healthy and continues to take salazopyrine permanently and celecoxib as needed. We conclude high rate response analyzing literature data and our case to combined therapy: arthroscopic or open surgery followed by RT along with complimentary pharmacotherapy.

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Experimental production of pigmented villonodular synovitis in the knee and ankle joints of rhesus monkeys

Cited by 47 publications

References 4 publications

Proliferating cell nuclear antigen labelling index in localised pigmented villo-nodular synovitis and its relationship to the size of nodules

Proliferating cell nuclear antigen labelling index in localised pigmented villo-nodular synovitis and its relationship to the size of nodules

Pigmented Villonodular Synovitis (PVNS) in Human and Animals: A Mini Review Article and Conclusive View

Pigmented Villonodular Synovitis for Combined Therapy

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