Experimental Production of Carotid Aneurysms

German, William J.; Black, Samuel P.

doi:10.1056/nejm195401212500303

Cited by 141 publications

(68 citation statements)

References 3 publications

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“…28 Bifurcation aneurysm models in dogs and rabbits can show recurrences with variable frequencies, despite treatment with various types of devices. 12,13,16,28,[41][42][43] Angiographic recurrences are rarely documented after coil embolization of the rabbit elastase aneurysms, but "microrecurrences" (only seen at pathology) are common.…”

Section: Angiographic Outcomesmentioning

confidence: 99%

“…38 The incidence of spontaneous thrombosis is influenced by the ratio of the volume of the aneurysm to the area of the neck (ostium). 12 Modifications of the ostium can also minimize thrombosis. 26,39 In rabbits, 1/7 studies assessed the patency of surgically created lateral wall aneurysms, and 8/10, of bifurcation aneurysms.…”

Section: Angiographic Outcomesmentioning

confidence: 99%

“…Inspired by the pioneering work of German and Black (1954), 12 surgical constructions in rabbits, swine, and dogs varied in complexity, from lateral wall types by end-to-side suturing of a segment of vein to carotid arteries, [13][14][15] to bifurcation aneurysms, anastomosing the right and left carotid arteries at the site of venous pouch implantation. 8,[16][17][18][19] (For a review, see Massoud et al 1994. 20 ) The elastase-induced aneurysm model, most frequently used in rabbits, 21,22 has been modified in various ways.…”

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confidence: 99%

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In Vivo Experimental Intracranial Aneurysm Models: A Systematic Review

Bouzeghrane

Naggara

Kallmes³

et al. 2009

AJNR Am J Neuroradiol

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SUMMARY: Animal models are necessary to develop and test innovations in aneurysm therapy before clinical introduction. This review aims at identifying the most likely candidates for standardizing preclinical testing of aneurysm devices. We systematically searched electronic databases for publications on animal aneurysm models from 1961-2008 to assess the methodologic quality of the studies and collect data on the patency and angiographic and pathologic outcomes of treatments. There has been a steady increase in the annual number of publications with time. Species that were most frequently used were dogs, rabbits, and rodents, followed by swine. Most publications are single-laboratory studies with variables and poorly validated outcome measures, a small number of subjects, and limited standardization of techniques. The most appropriate models to test for recurrences after endovascular occlusion were the surgical bifurcation model in dogs, and the elastase-induced aneurysm model in rabbits. A standardized multicenter study is needed to improve the preclinical evaluation of endovascular devices in aneurysm therapy.

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Section: Angiographic Outcomesmentioning

confidence: 99%

Section: Angiographic Outcomesmentioning

confidence: 99%

mentioning

confidence: 99%

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In Vivo Experimental Intracranial Aneurysm Models: A Systematic Review

Bouzeghrane

Naggara

Kallmes³

et al. 2009

AJNR Am J Neuroradiol

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“…Lateral wall aneurysms were surgically created in the right common carotid artery of canines as previously described. 1,14,15 Prior to embolization, animals were given an intravenous bolus injection of 3000 IU heparin, followed by a maintenance injection of 500 IU every 30 minutes during the procedure to control clotting. Postoperatively, animals were placed on chronic aspirin at a dose of 81.25 mg/day.…”

Section: Surgical Aneurysm Creationmentioning

confidence: 99%

In vivo embolization of lateral wall aneurysms in canines using the liquid-to-solid gelling PPODA-QT polymer system: 6-month pilot study

Brennecka

Preul

Becker

et al. 2013

JNS

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Object Over the past 20 years, endovascular embolization has become the preferred method of treating cerebral aneurysms. While there are many embolic devices on the market, none is ideal. In this study the authors investigated the use of a liquid-to-solid gelling polymer system—that is, poly(propylene glycol) diacrylate and pentaerythritol tetrakis (3-mercaptopropionate) (PPODA-QT)—to embolize in vivo aneurysms over a 6-month period. Methods Experimental aneurysms were created in the carotid arteries of 9 canines. Aneurysms were embolized with the polymer only (PPODA-QT, 3 dogs), filled with PPODA-QT after placement of a “framing” platinum coil (coil + PPODA-QT, 3 dogs), or packed with platinum coils (coils only, 3 dogs). Aneurysm occlusion was angiographically monitored immediately and 6 months after embolization. After 6 months, the ostial regions of explanted aneurysms were assessed macroscopically and histologically. Results All aneurysms showed 100% angiographic occlusion at 6 months, but turbulent blood flow was observed in 1 coils-only sample. Ostial regions of explanted coils-only aneurysms showed neointimal tissue surrounding individual coils but no continuous tissue layer over the aneurysm neck. All PPODA-QT aneurysms displayed smooth ostial surfaces, but 2 of 3 coil + PPODA-QT aneurysms showed polymer (unassociated with the coil) protruding into the vessel lumen, contributing to rough ostial surfaces. Neointimal tissue was present in PPODA-QT and coil + PPODA-QT aneurysms and covered smooth ostial surfaces more completely than in coils-only aneurysms. Conclusions This study compared neointimal tissue overgrowth in the ostium of experimental aneurysms embolized with PPODA-QT, PPODA-QT plus a framing coil, or coils alone. The coils-only and coil + PPODA-QT groups showed rough and discontinuous ostial surfaces, which hindered neointimal tissue coverage. The PPODA-QT aneurysms consistently produced smooth ostial surfaces that facilitated more complete neointimal tissue coverage over aneurysm necks.

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“…While many experimental aneurysm models have been reported by using canines, rabbits, swine, and rodents, [1][2][3][4] a recent systematic review of in vivo experimental aneurysm models demonstrated that the most useful models for preclinical testing on aneurysm-treatment devices were the elastase-induced aneurysms in rabbits and the venous pouch aneurysms in dogs. 5 Since its introduction by Cloft et al 6 and Altes et al, 7 the rabbit elastase-induced aneurysm, by using the stump of the right CCA, has been widely used.…”

mentioning

confidence: 99%