Experimental Phantom Lesion Detectability Study Using a Digital Breast Tomosynthesis Prototype System

Abstract

Tomosynthesis has the potential to increase the sensitivity of digital mammography. Overlapping structures from out-of-plane tissue can be removed in the tomosynthesis reconstruction process, thereby enhancing the diagnostic accuracy.

Full Field Digital Mammography (FFDM) versus CMOS Technology versus Tomosynthesis (DBT) - Which System Increases the Quality of Intraoperative Imaging?

“…Hierbei gab es ebenfalls eine Innovation von konventionellen, über Speicherfolien zu volldigitalen Systemen [14][15][16][17][18][19][20][21][22] bis hin zur CMOS-Technologie [23] und dem Einsatz der Tomosynthese [24]. Durch die Neuentwicklung der digitalen Brusttomosynthese (DBT) [25][26][27][28][29][30][31][32] besteht nun auch die Möglichkeit der Erstellung intraoperativer Präparateradiogramme [24]. Die 3 Untersucher beurteilten zufallsverteilt (Zufallsgenerator), nur in Kenntnis des Ausgangsbefundes (histologisch Diagnose B5, diagnostisch BI-RADS 6), intraoperativ auf einem Befundungsmonitor die 200 Präparate (Präparateradiografie) mit dem BioVision™-System, 2 Ebenen (System 2) und der Tomosynthese (1 Ebene) einerseits sowohl anhand der Projektionsbilder als auch im Cine-Mode (System 3), wobei als Standard das Präparatera-diogramm in 2 Ebenen (System 1) definiert wurde, aufgrund dessen bei 44 Patientinnen eine Re-Exzision durchgeführt wurde.…”

“…Here too, there has been a gradual switch from conventional systems using slides to fully digital systems [14][15][16][17][18][19][20][21][22] to CMOS technology [23] and Tomosynthesis [24]. The most recent developments in digital breast tomosynthesis (DBT) [25][26][27][28][29][30][31][32] make it possible to create specimen radiograms intraoperatively [24]. The 3 investigating radiologists assessed 200 specimens (specimen radiograms) randomly assigned to them (random generator) with only a prior knowledge of the initial pathology findings (histological classification B5, diagnostic classification BI-RADS 6).…”

Glandular radiation dose in tomosynthesis of the breast using tungsten targets

“…Recently, several of the patient and simulation studies reporting the initial results of tomosynthesis imaging of the breast have been performed with x-ray systems that use tungsten as the target material. (4,(11)(12)(13)(14) X-ray spectra from tungsten targets are very different from molybdenum or rhodium target spectra, and their dosimetric characteristics can be expected to reflect this difference in x-ray energy distribution. The above mentioned tomosynthesis dosimetry study only included molybdenum and rhodium target x-ray spectra, and therefore those results are not applicable to tomosynthesis examinations performed with x-ray tubes with tungsten targets.…”

Breast tomosynthesis: Dosimetry and image quality assessment on phantom

“…The combination of tomosynthesis with digital mammography increases diagnostic accuracy [6][7][8][9][10][11][12][13][14][15] and reduces recall rates by 30 to 40% [8,9]. In the United States, tomosynthesis was approved by the Food and Drug Administration in 2011 [16].…”