Experimental phaeohyphomycosis

Abstract

The authors performed an experimental infection of the rabbit eye with Wangiella dermatitidis which had been isolated from the corneal ulcer of a patient. The fungus was inoculated into the front chamber and the vitreous body. The disease showed a trend to spontaneous recovery. The individual phases of the experimental infection were followed by histology and electronmicroscopy, both TEM and SEM. Different stages of development of the polymorphous fungus, as sclerotic bodies, mycelial filaments and yeast-like cells, could be demonstrated.

Delayed-onset postoperative endophthalmitis secondary toExophiala

“…An interesting observation is that this case of Exophiala endophthalmitis was confined to the anterior segment, with no evidence of vitreous involvement. Furthermore, experiments in an animal model have shown that injection of Exophiala organisms into the vitreous cavity fails to produce endophthalmitis 8. Perhaps nutritional or other trophic features of the vitreous cavity are inhospitable to the growth of this fastidious organism.…”