Experimental pastes containing niobophosphate and 45S5 bioactive glasses for treatment of dentin hypersensitivity: dentin permeability and tubule obliteration

Freitas, Samantha Ariadne Alves de; Ferreira, Paulo Vítor Campos; Carvalho, Edilausson Moreno; Aldaz, Mayra Alejandra Núñez; Loguércio, Alessandro Dourado; Grazziotin‐Soares, Renata; Carvalho, Ceci Nunes; Pereira, Adriana de Fátima Vasconcelos; Bauer, José

doi:10.1007/s00784-022-04595-7

Cited by 2 publications

(1 citation statement)

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“…However, commonly used granule-like or bulk scaffolds exhibited operational inconvenience. More recently, bone cements, bone putties [ 2–4 ], 3D printing scaffolds [ 5–9 ] and hydrogels [ 10–13 ], which focused on providing shape matching property, have gained wide interests. Although bioactive bone cements and putties products like NovaBone Putty ® have been widely used in clinic, inorganic particles in this system hardly bond with each other and with the liquid phase, which will risk collapse and reduction of the reconstruction effect.…”

Section: Introductionmentioning

confidence: 99%

Phosphoserine enhanced Cu-doped bioactive glass dynamic dual-network hydrogel for craniofacial bone defect repair

Liu

Wang

Luo

et al. 2023

Regenerative Biomaterials

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Flexible hydrogels containing various osteogenic inorganic constituents, which can accommodate complicated shape variations, are considered as ideal grafts for craniofacial bone defect reconstruction. However, in most hybrid hydrogels, poor interaction between the polymer network and particles has detrimental effects on hydrogel rheological and structural properties, clinical manipulation and repair efficacy. In this article, we designed and prepared a series of hyaluronic acid composite hydrogel containing Cu doped bioactive glass (CuBG) and phosphoserine (PS), in which hyaluronic acid was modified by methacrylate groups and phenylboronic acid groups to form a double crosslinked network. PS acted as an interaction bridge of CuBG particles and HAMA-PBA network to improve the mechanical properties of the composite hydrogels. The CuBG/PS hydrogels exhibited suitable rheological properties (injectable, self-healing, shape-adaptable), bone tissue integrating ability and anti-bacterial property. Meanwhile, we found that CuBG and PS have synergistic effect on improving osteogenic efficiency both in vitro and in vivo, particularly when the ratio of CuBG to PS is lower than 3 (9CB/3 PS). This work provided a versatile and scalable approach to enhanced the interaction within inorganic particles and polymer network in hydrogels without extra modification on components.

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Section: Introductionmentioning

confidence: 99%