Experimental non-specific immunotherapy

Sadler, T E; Castro, J. E.

doi:10.1007/978-94-010-9418-4_14

Cited by 3 publications

(3 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Much research and discussion has centered around the therapy of experimental and human cancers using agents whose traditional biologic function is modification of RES activity (Gutterman et al, 1978;Bast and Bast, 1976;Sadler and Castro, 1978). The rationale for evaluation of RES stimulants as anti-tumor agents has often been based on the premise that they activate cells of the host defense systems to become potentially cytotoxic for malignant cells (Levy and Wheelock, 1974;Schultz et al, 1976).…”

Section: Discussionmentioning

confidence: 99%

Metastasis: Reticuloendothelial system and organ retention of disseminated malignant cells

Glaves

1980

Intl Journal of Cancer

View full text Add to dashboard Cite

The lung retention patterns of B16 melanoma cells were determined after intravenous injection of [125l]dUrd-labelled tumor cells into B16 melanomabearing mice. Experiments were performed with mice undergoing acute or chronic reactions to bacterial endotoxin or zymosan, both of which were shown to modify the activity of the reticuloendothelial system as assessed by carbon clearance assays. On the one hand, the release of arrested melanoma cells from the lungs was retarded in mice with both endotoxin-and zymosan- induced acute inflammation. There was a parallel increase in the numbers of pulmonary tumor nodules which developed after injection of non-radiolabelled melanoma cells into similarly treated groups of mice. On the other hand, fewer tumor cells were retained in the lungs of mice undergoing chronic responses to endotoxin, and fewer pulmonary tumor nodules subsequently arose after injection of unlabelled cells. However, in mice pre-treated with zymosan, retention of melanoma cells was not different from that in controls and greatly increased numbers of pulmonary nodules grew in zymosan pre-treated mice receiving non-radiolabelled cells. These experiments were discussed in terms of the contribution of the reticuloendothelial system to the release of arrested cancer cells from the pulmonary vasculature.

show abstract

Section: Discussionmentioning

confidence: 99%

Metastasis: Reticuloendothelial system and organ retention of disseminated malignant cells

Glaves

1980

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…Accordingly, live, attenuated, or killed facultative intracellular pathogens, known to augment immunity to infectious agents, were among the earliest factors introduced in cancer immunotherapy. Such microbial agents, particularly BCG and CP, are capable of inducing anti-tumor activity in defined animal models and in some solid human tumors (Laucius et al, 1974;Scott, 1974;Sadler and Castro, 1978;Herberman, 1980;Woodruff, 1980;Morales and Ersil, 1982). Such treatments may also be effective in autochthonous tumors without detectable immunogenicity, suggesting that nonspecific mechanisms, as mediated by activated MP, NK and/or LAK cells, are dominant (Laucius et al, 1974;Scott, 1974;Sadler and Castro, 1978;Oldham, 1987).…”

mentioning

confidence: 97%

“…Such microbial agents, particularly BCG and CP, are capable of inducing anti-tumor activity in defined animal models and in some solid human tumors (Laucius et al, 1974;Scott, 1974;Sadler and Castro, 1978;Herberman, 1980;Woodruff, 1980;Morales and Ersil, 1982). Such treatments may also be effective in autochthonous tumors without detectable immunogenicity, suggesting that nonspecific mechanisms, as mediated by activated MP, NK and/or LAK cells, are dominant (Laucius et al, 1974;Scott, 1974;Sadler and Castro, 1978;Oldham, 1987). The present work is a further attempt to analyze the complex processes involved in the interaction of tumor and host in vivo, utilizing the operationally simple and reproducible DA rat D-12 ascites tumor model (Keller, 1976(Keller, , 1977(Keller, , 1980.…”

mentioning

confidence: 97%

Resistance to a non‐immunogenic tumor, induced by Corynebacterium parvum or Listeria monocytogenes, is abrogated by anti‐interferonγ

Keller

Keist

Leist

et al. 1990

Intl Journal of Cancer

View full text Add to dashboard Cite

The complex processes that determine the outcome of the interaction of tumor and host were explored in the operationally simple and reproducible rat D-12 ascites tumor model. Animals exhibit weak spontaneous resistance against this tumor that is not augmented by repeated inoculation, by various routes, of irradiated syngeneic D-12 tumor cells, but considerably enhanced after local administration of heat-killed Corynebacterium parvum (CP) or Listeria monocytogenes (LM) organisms. Inoculation of conventional or monoclonal anti-rat IFN gamma antibodies into the same compartment did not affect spontaneous tumor resistance, but largely abrogated the tumor-protective effect triggered by CP or LM. Our findings support the concept that IFN gamma, produced by T cells in the course of the specific immune response raised against immunogenic micro-organisms, is able to enhance and to maintain local tumor resistance and thus to strengthen the capacity of the host to cope with a non-immunogenic tumor.

show abstract

Complement and Cancer: Activation of the Alternative Pathway as a Theoretical Base for Immunotherapy

Cooper¹

1985

Advances in Immunity and Cancer Therapy

View full text Add to dashboard Cite

Experimental non-specific immunotherapy

Cited by 3 publications

References 65 publications

Metastasis: Reticuloendothelial system and organ retention of disseminated malignant cells

Metastasis: Reticuloendothelial system and organ retention of disseminated malignant cells

Resistance to a non‐immunogenic tumor, induced by Corynebacterium parvum or Listeria monocytogenes, is abrogated by anti‐interferonγ

Complement and Cancer: Activation of the Alternative Pathway as a Theoretical Base for Immunotherapy

Contact Info

Product

Resources

About