Experimental nickel dermatitis

Stewart, Sloan G.; Cormia, Frank E.

doi:10.1016/s0021-8707(34)90135-0

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1935

1981

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Cited by 11 publications

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“…Experimental sensitization to nickel in guinea pigs has been reported by some investigators (10,13,14). Their results, however, have not been confirmed by other investigators (4,5,12).…”

mentioning

confidence: 88%

Attempts to induce sensitization in guinea pigs with nickel complexes

Samitz¹,

Katz²,

Scheiner³

et al. 1975

Acta Derm Venereol

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A technique for the induction of sensitization in pigs with a nickel-alanine conjugate has been reported by other investigators. Similar results were observed in our experiments in mini-pigs. However, using the identical technique, we were unable to induce sensitization in guinea pigs with NiSO4, with nickel-alanine or other nickel-amino acid complexes, or with a complex of nickel with soluble guinea pig skin extract. These results indicate that nickel-amino acid complexes and nickel-guinea pig skin complex were not antigenic in guinea pigs with this technique. Hypotheses for the apparent failure to induce sensitization are proposed.

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“…Experimental sensitization to nickel in guinea pigs has been reported by some investigators (10,13,14). Their results, however, have not been confirmed by other investigators (4,5,12).…”

mentioning

confidence: 88%