Experimental neurolathyrism in chicks

Sharan, R.

doi:10.1038/sc.1972.47

Cited by 2 publications

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“…The dominating clinical features are weakness and spasticity of the lower limbs and exceptionally of all four limbs, ataxia, clonus, exaggerated tendon reflexes, and extensor plantar re sponse. Bladder and bowel disturbances and ary metabolite present in the legume Lathyrus sativus (local name: khesari) [1][2][3][4][5][6]. This legume is grown and consumed by sev eral hundred million people in developing countries like Ethiopia, the sub-Saharian re gion, India, Bangladesh, Pakistan, Nepal, and China.…”

Section: Introductionmentioning

confidence: 99%

Epidemiological Study of Lathyrism in Northwestern Districts of Bangladesh

Haque¹,

Hossain²,

Wouters

et al. 1996

Neuroepidemiology

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Two northwestern districts of Bangladesh with a population of 629,752 were surveyed from June 1991 to March 1993 to detect and follow up lathyrism patients. Out of 2,567 neurological patients, 882 were diagnosed as having lathyrism, giving a prevalence rate of 14.0/10,000. This prevalence was higher among young males: only 12.9% of the patients were female, and only 19.3% of the patients were over 30 years of age at onset of the disease. The average family size was 4.6 members. In the surveyed area, 730 families were evaluated: 622 families had only 1 affected member, and 108 families had 2–8 affected members. Most of the patients were working, while only 4% were not. The majority of the patients had a very low intake of animal protein. A few cases of human T-lymphotropic virus infection and osteolathyrism were found during this study.

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Section: Introductionmentioning

confidence: 99%

Epidemiological Study of Lathyrism in Northwestern Districts of Bangladesh

Haque¹,

Hossain²,

Wouters

et al. 1996

Neuroepidemiology

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“…β-L-ODAP is a potent agonist (Bridges et al, 1989) at α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) glutamate receptor subtype ( Figure 6D). Feeding experiments with Lathyrus sativus induced paraparesis in chickens (Sharan, 1973), in rats (Geiger et al, 1933), and in ascorbic acid deficient guinea pigs and primates (Jahan and Ahmad, 1993). Fortification of Lathyrus sativus flour with graded doses of β-L-ODAP induced dose dependent spastic motor changes in monkeys (Spencer et al, 1986).…”

Section: Discussionmentioning

confidence: 99%

El Niño-southern oscillations and lathyrism epidemics

Oluwole

2015

Front. Environ. Sci.

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Epidemics of lathyrism, a neurological syndrome of spastic paraparesis, have occurred during severe droughts in Europe, Asia, and Africa for millenia. Causation is linked to exposure to β-N-oxalyl-L-α,β-diaminopropionic acid (β-L-ODAP), a neurotoxin in Lathyrus sativus. Lathyrism shares neurological features with konzo, a syndrome of predominantly spastic paraparesis which occurs during droughts in East and Central Africa and is linked to El Niño activity. This study was done to determine the relationship of lathyrism epidemics to phases of El Niño-southern oscillation (ENSO) and Pacific decadal oscillation (PDO), and to propose a model to explain why the geospatial distributions of lathyrism and konzo are non-overlapping. Contingency table of phases of ENSO and occurrence of lathyrism epidemics in Central Provinces, India from 1833-1902 was created and odds ratio was calculated. Wavelet spectra of time series of annual occurrence of lathyrism in Rewah district, India, and its coherence with ENSO and PDO from 1894 to 1920 were performed. Lathyrism epidemic was associated with El Niño phase of ENSO, odds ratio 378 (95% 32-4475). Global spectra showed peaks at periodicities of 2.5 and 4.6 years for lathyrism; 2.7 and 5.0 years for PDO; and 2.5, 4.6, 7.0 years for ENSO. Spectrograms showed time-varying periodicities of 2.5-3.5 and 4.5-5.5 years for lathyrism; 2.0-3.0 and 6.5-9.0 years for ENSO; and 3.5 and 5.0 years for PDO, p < 0.0001. Spectral coherence were at 2.0-3.5 and 4.5-5.0 years for ENSO and lathyrism p < 0.0001, and 5.0 years for PDO and lathyrism p < 0.05. The droughts of El Niños initiate dependence on Lathyrus sativus, which exposes the population to neurotoxic β-L-ODAP. Public health control of lathyrism epidemics should include development of models to forecast El Niños and initiate food programmes in susceptible areas.

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Experimental neurolathyrism in chicks

Cited by 2 publications

References 1 publication

Epidemiological Study of Lathyrism in Northwestern Districts of Bangladesh

Epidemiological Study of Lathyrism in Northwestern Districts of Bangladesh

El Niño-southern oscillations and lathyrism epidemics

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