Experimental myocardial infarction

Gilmour, David P.; Hood, William B.; Kumar, Raj; Asimacopoulos, Panayiotis J.; Norman, John C.; Abelmann, Walter H.

doi:10.1016/0002-9149(73)90265-8

Cited by 5 publications

(1 citation statement)

References 105 publications

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“…The results showed a 10% increase in ejection fraction in the HBO group, rapid pain resolution and attenuated creatine phosphokinase, although the results were not statistically significant. Gilmour et al (27), subjected dogs to a brief period (20 min) of 3 ATA HBO prior to occlusion of the coronary artery followed by a second period of HBO immediately after occlusion and concluded that HBO did not improve left ventricular function impaired by MI. The results of this study are difficult to interpret, as it has been reported that tissue oxygen tensions remain elevated after HBO treatment has concluded.…”

Section: Discussionmentioning

confidence: 99%

Supplemental Oxygen Protects Heart Against Acute Myocardial Infarction

Prabhat

Kuppusamy

Naidu

et al. 2018

Front. Cardiovasc. Med.

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Myocardial infarction (MI), which occurs often due to acute ischemia followed by reflow, is associated with irreversible loss (death) of cardiomyocytes. If left untreated, MI will lead to progressive loss of viable cardiomyocytes, deterioration of cardiac function, and congestive heart failure. While supplemental oxygen therapy has long been in practice to treat acute MI, there has not been a clear scientific basis for the observed beneficial effects. Further, there is no rationale for the amount or duration of administration of supplemental oxygenation for effective therapy. The goal of the present study was to determine an optimum oxygenation protocol that can be clinically applicable for treating acute MI. Using EPR oximetry, we studied the effect of exposure to supplemental oxygen cycling (OxCy) administered by inhalation of 21–100% oxygen for brief periods (15–90 min), daily for 5 days, using a rat model of acute MI. Myocardial oxygen tension (pO2), cardiac function and pro-survival/apoptotic signaling molecules were used as markers of treatment outcome. OxCy resulted in a significant reduction of infarct size and improvement of cardiac function. An optimal condition of 30-min OxCy with 95% oxygen + 5% CO2 under normobaric conditions was found to be effective for cardioprotection.

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Section: Discussionmentioning

confidence: 99%

Supplemental Oxygen Protects Heart Against Acute Myocardial Infarction

Prabhat

Kuppusamy

Naidu

et al. 2018

Front. Cardiovasc. Med.

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Cardiovascular Aspects of Hyperbaric Oxygen Therapy

Bové¹

2008

Physiology and Medicine of Hyperbaric Oxygen Therapy

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Effect of regional ischemia on the left ventricular end-systolic pressure-volume relationship of isolated canine hearts.

Sunagawa

Maughan²,

Sagawa

1983

Circulation Research

148

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We studied the effects of regional ischemia on the left ventricular isovolumic end-systolic pressure-volume relationship (ESPVR) in six excised, blood-perfused canine ventricles. We created different extents of regional ischemia by ligating various branches of the coronary arteries while keeping the coronary arterial pressure constant (80 mm Hg). The extent of regional ischemia (Rm) relative to the total mass of the left ventricular myocardium was determined by regional myocardial blood flow measured by the radioactive microsphere technique. With regional ischemia, the ESPVR shifted rightward without significant change in slope in the physiologic end-systolic pressure range. In the subphysiological end-systolic pressure range, however, its slope became lower than control. In order to quantify the degree of the rightward shift, we measured the extrapolated volume axis intercept (Vo) by fitting a straight line to the ESPVR in the physiological range under control and ischemic conditions. The shift in Vo (delta Vo) associated with ischemia was linearly correlated with Rm (delta Vo = 50.7Rm-0.6, n = 28, r = 0.944, P less than 0.001). We conclude that the major effect of acute regional ischemia on the ESPVR in the physiological pressure range is a parallel rightward shift. This forms a striking contrast to the effect of global ischemia (under which only the slope is affected without a substantial change in Vo).

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Experimental myocardial infarction

Cited by 5 publications

References 105 publications

Supplemental Oxygen Protects Heart Against Acute Myocardial Infarction

Supplemental Oxygen Protects Heart Against Acute Myocardial Infarction

Cardiovascular Aspects of Hyperbaric Oxygen Therapy

Effect of regional ischemia on the left ventricular end-systolic pressure-volume relationship of isolated canine hearts.

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