Experimental Models on Effects of Psychostimulants

Kõks, Sulev

doi:10.1016/bs.irn.2015.03.002

Cited by 5 publications

(1 citation statement)

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“…This is supported by the intimate link between neural substrates for drive and motor activity through dopaminergic signaling (Wise and Bozarth, 1987; McGinty et al, 2013; Kõks, 2015). Thus, food-restriction triggers an increase in ambulatory activity in many mammals, presumably to facilitate foraging behavior (Koubi et al, 1991; Day, Kyriazakis and Lawrence, 1995; Weed et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Motivated state control in larval zebrafish: behavioral paradigms and anatomical substrates

Horstick

Mueller

Burgess

2016

Journal of Neurogenetics

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Over the course of each day, animals prioritize different objectives. Immediate goals may reflect fluctuating internal homeostatic demands, prompting individuals to seek out energy supplies or warmth. At other times, the environment may present temporary challenges or opportunities. Homeostatic demands and environmental signals often elicit persistent changes in an animal’s behavior to meet needs and challenges over extended periods of time. These changes reflect the underlying motivational state of the animal. The larval zebrafish has been established as an effective genetically tractable vertebrate system to study neural circuits for sensory-motor reflexes. Fewer studies have exploited zebrafish to study brain circuits that control motivated behavior. In part this is because appropriate conceptual frameworks, anatomical knowledge, and behavioral paradigms are not yet well established. This review sketches a general conceptual framework for studying motivated state control in animal models, how this applies to larval zebrafish and the current knowledge on neuroanatomical substrates for state control in this model.

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