2015
DOI: 10.1590/s0102-865020150120000006
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Experimental models of renal dysfunction in female rats. Functional and histological aspects after unilateral nephrectomy or ligation of right renal vein with kidney preservation

Abstract: PURPOSE:To compare renal dysfunction after right nephrectomy and ligation of the right renal vein with preservation of kidney. METHODS:Animals' weight, pH, density, protein in urine and histological samples of the kidneys were evaluated. Fifteen female rats (Wistar) were divided into three groups. In the control group, right renal vein dissections were performed. In the second group, the right nephrectomy was performed. In the third group, the right renal vein was ligated and the kidney was preserved. Urine sa… Show more

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Cited by 4 publications
(5 citation statements)
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“…It is a technique that does not involve special costs, with a low impact on the status of the experimental animal. (8,9) We mention the fact that the animals after the surgery will be placed in spaces where a constant temperature of 25 degrees Celsius is ensured, a 12-hour day/night cycle and food and water ad libitum (table no. 1).…”
Section: Resultsmentioning
confidence: 99%
“…It is a technique that does not involve special costs, with a low impact on the status of the experimental animal. (8,9) We mention the fact that the animals after the surgery will be placed in spaces where a constant temperature of 25 degrees Celsius is ensured, a 12-hour day/night cycle and food and water ad libitum (table no. 1).…”
Section: Resultsmentioning
confidence: 99%
“…To further accelerate the decline of renal function, we performed UNx in addition to salt loading. By promoting renal dysfunction via reducing the number of nephrons, UNx and 5/6 nephrectomy in rats and mice are widely used as experimental models of chronic kidney disease (CKD) 25‐27 …”
Section: Discussionmentioning
confidence: 99%
“…The incidence of CIN dramatically increases in patients with pre-existing renal impairments [24]. Significant alterations in renal function parameters have been observed after unilateral ligation of the renal vein [25]. At the same time, a more marked increase in plasma creatinine levels has been observed in rats with a unilateral ureteral obstruction [26].…”
Section: Discussionmentioning
confidence: 99%