Experimental Models of Depression: An Overview to Validity and Reliability Criteria

Özkartal, Ceren Şahin; Arıcıoğlu, Feyza

doi:10.5336/jlabanim.2017-59277

Cited by 2 publications

(1 citation statement)

References 38 publications

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“…Depression is a psychiatric disorder that ranks first among neurological and mental disorders [1,2]. Today, this disease, which can disrupt normal functioning in many societies worldwide, causes depressive thoughts, deterioration in cognitive and social functions, severely impair the patient's quality of life, and significantly increases morbidity and mortality [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Etiopathogenesis of depression and experimental depression models used in preclinical studies

Kandemir

2023

Eur J Life Sci

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Depression is the most frequent psychiatric illness among mood disorders, affecting approximately 10% of adults. Especially recurrent and moderate/severe depression can become a serious public health problem by impairing people’s life quality. The monoamine hypothesis is the most widely accepted hypothesis for clarifying the pathophysiology of depression. Depression’s pathogenesis and etiology, however, are still poorly understood. Tricyclic antidepressants, monoamine oxidase inhibitors, selective serotonin or noradrenaline reuptake inhibitors, different atypical antidepressants, and electroconvulsive therapy are currently available therapies for depression. Although these treatment options are effective, a large number of patients do not respond to treatment or do not attain long-term remission. Furthermore, present antidepressants used in clinics have disadvantages such as delayed onset of effects, side effects, and patient compliance problems. Therefore, the discovery of new antidepressant medications is crucial. Animal models are critical in investigating the etiology of depression and developing novel treatments. Hence, in this review, the main mechanisms involved in the etiopathogenesis of depression and the experimental depression models used in preclinical studies have been demonstrated.

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Section: Introductionmentioning

confidence: 99%

Etiopathogenesis of depression and experimental depression models used in preclinical studies

Kandemir

2023

Eur J Life Sci

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Depression models in experimental animals

Demirdaş

2018

Journal of Cellular Neuroscience and Oxidative Stress

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Speakers Speak No. 1. Pathophysiology of cation channels in pain: Focus on TRP Channels. Mustafa NAZIROĞLU…………….….………………….………………………………..………….776 Speak No. 2. Calcium imaging techniques in cell lines. Laszlo PECZE………….…………….………………….………….……………………..…………777 Speak No. 3. Western-blot, PCR and immunofluorescence analysis in mitochondrial biogenesis studies. Denis ROUSSEAU…………………….………………….………………………………..…………778 Speak No. 4. Intravenous NAD + effectively increased the NAD metabolome, reduced oxidative stress and inflammation, and increased expression of longevity genes safely in elderly humans.

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Experimental Models of Depression: An Overview to Validity and Reliability Criteria

Cited by 2 publications

References 38 publications

Etiopathogenesis of depression and experimental depression models used in preclinical studies

Etiopathogenesis of depression and experimental depression models used in preclinical studies

Depression models in experimental animals

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