Experimental Models in Primates for Reconstructive Surgery Utilizing Tissue Transplants

Ep, Egerszegi; Dd, Samulack; Rk, Daniel

doi:10.1097/00000637-198411000-00010

Cited by 36 publications

(18 citation statements)

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“…However, ethical concerns with respect to the use of companion animals in research have reduced their use. Nonhuman primate (NHP) models were developed in the 1980s and swine models at the turn of the century [12,14]. Whilst all the species above have advantages, NHPs may be the optimum in terms of the ability to assess functional outcomes.…”

Section: Historical Perspectivesmentioning

confidence: 99%

“…Initial immunosuppressive strategies in VCA were based on those used in solid organ transplantation, however it was found that levels of immunosuppression required in primates were much higher in VCA than in renal transplantation [14]. The heterogeneity of VCA grafts including diverse tissues such as skin, bone, muscle, tendon, nerve, vascular and lymphoid tissues is a defining characteristic and poses unique challenges as well as opportunities for discovery.…”

Section: Tissue Type Compositionmentioning

confidence: 99%

“…Orthotopic models in small and large animals have been designed to address these questions. Technical success has been reported in orthotopic mouse hind limb transplantation [23,24] and motor and sensory nerve functions have been positively evaluated in orthotopic limb transplants in both rodents and NHPs [14,15,22]. Nonetheless, measuring functional recovery is a challenge and various strategies have been attempted.…”

Section: Heterotopic Vs Orthotopicmentioning

confidence: 99%

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Preclinical Models in Vascularized Composite Allotransplantation

2015

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Vascularized composite allotransplantation (VCA) has the potential to reconstruct any non-visceral tissue defect, using like for like tissue, delivering optimal form and function. Over 150 VCA transplants have been performed worldwide; however, this treatment remains experimental. Things systematically tried in the clinic should follow thorough science and tested in a model that allows predicting as possible the safety of the procedure. This is generally the function of animal experimentation. Advantages of preclinical models include greater control of bias, of subject numbers and of variables compared to clinical trials. Limitations include differences between species in anatomy and physiology as well as ethical, logistical and technical constraints. Multiple models have been described; however, no single model is ideal in all areas. This paper reviews historical perspectives, current models and future direction in VCA research.

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Section: Historical Perspectivesmentioning

confidence: 99%

Section: Tissue Type Compositionmentioning

confidence: 99%

Section: Heterotopic Vs Orthotopicmentioning

confidence: 99%

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Preclinical Models in Vascularized Composite Allotransplantation

2015

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“…At the beginning of the third millennium, could we (as a society) consider transplantation not only to prolong or to save life, but also to improve quality of life? (12)(13)(14)(15)(16)(17)(18).…”

Section: Quality or Quantity?mentioning

confidence: 99%

Hand Transplantation: The Milan Experience

Lanzettà¹,

Nolli²,

Vitale³

et al. 2007

Polish Journal of Surgery

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The authors describe the most critical aspects of transplantation of the hand. Three successful cases are presented from the Italian Hand Transplantation National Program. The key issues of this new type of surgical reconstruction for major amputations are selection criteria of suitable candidates, technical aspects of surgery, postoperative regime and functional rehabilitation. Other important aspects are staff requisites and organisation of the clinical trial, ethical and legal implications, dealing with the media. The authors comment on the fact that we might be ready to accept that almost anything could come from a cadaver, even if it is not a life-saving organ, to reconstruct missing parts and restore anatomical integrity and, especially, function.

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“…Previous descriptions of gastrocnemius transplantation have concentrated on transplantation biology and have only summarily described the muscle and its transplantation technique. [1][2][3][4][5][6] In this series of experiments, we studied the anatomy of this muscle in detail and assessed its technical reliability as a transplant model.…”

mentioning

confidence: 99%

Microvascular transplant of the gastrocnemius muscle in rats

Tonken¹,

Zhang

Sudekum

et al. 1993

Microsurgery

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The rat gastrocnemius muscle can serve as a vascularized, innervated muscle transplant model. To establish the anatomic and technical details of this model, we performed ten gastrocnemius transplants and collected data on muscle weight, dimension, and vessel caliber from each muscle. The muscle, consisting of medial and lateral heads, is supplied by pairs of sural vessels averaging 0.2 mm in diameter. These vessels, however, can be taken in continuity with the femoral vessels (averaging 1.0-1.6 mm in diameter), which are used for transplantation. The muscles weighed an average of 2.8 g, and the average pedicle length was 24 mm. Eight of ten transplanted muscles were viable with intact circulation at 72 hr. The gastrocnemius transplant was technically reliable, and the muscle bulk and contour could allow biochemical and functional studies. Donor site morbidity limits this model to transplantation studies.

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Experimental Models in Primates for Reconstructive Surgery Utilizing Tissue Transplants

Cited by 36 publications

References 0 publications

Preclinical Models in Vascularized Composite Allotransplantation

Preclinical Models in Vascularized Composite Allotransplantation

Hand Transplantation: The Milan Experience

Microvascular transplant of the gastrocnemius muscle in rats

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