Experimental Models for Understanding B Lymphocyte Formation

Kincade, Paul W.

doi:10.1016/s0065-2776(08)60032-2

Cited by 120 publications

(60 citation statements)

References 462 publications

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“…In particular, we also observed some B cell activityrelated GO terms, such as B cell activation involved in the immune response, B cell cytokine production, B cell proliferation and B cell cytokine production. We confirmed that the BF can provide a useful experimental model of the development of B lymphocytes (Kincade, 1987). Korte et al analyzed the proteome dynamics of the chicken BF organ during embryonic and post hatch development, and they have found that genes such as retinal-binding protein 5, the actin-cytoskeleton, vinculin, gelsolin, and chloride intracellular channel 2 are most likely critical to biological processes such as the migration of B cell precursors into the bursa anlage (Korte et al, 2013).…”

Section: The Gene Ontology Differs In Bursa Of Fabricius Between Two supporting

confidence: 67%

The Gene Ontology Differs in Bursa of Fabricius Between Two Breeds of Ducks Post Hatching by Enriching the Differentially Expressed Genes

Liu

Zhang

et al. 2018

Rev. Bras. Cienc. Avic.

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The bursa of Fabricius (BF) is the central humoral immune organ unique to birds. The present study investigated the possible difference on a molecular level between two duck breeds. The digital gene expression profiling (DGE) technology was used to enrich the differentially expressed genes (DEGs) in BF between the Jianchang and Nonghua-P strains of ducks. DGE data identified 195 DEGs in the bursa. Gene Ontology (GO) analysis suggested that DEGs were mainly enriched in the metabolic pathways and ribosome components. Pathways analysis identified the spliceosome, RNA transport, RNA degradation process, Jak-STAT signaling pathway, TNF signaling pathway and B cell receptor signaling pathway. The results indicated that the main difference in the BF between the two duck strains was in the capabilities of protein formation and B cell development. These data have revealed the main divergence in the BF on a molecular level between genetically different duck breeds and may help to perform molecular breeding programs in poultry in the future.

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Section: The Gene Ontology Differs In Bursa Of Fabricius Between Two supporting

confidence: 67%

The Gene Ontology Differs in Bursa of Fabricius Between Two Breeds of Ducks Post Hatching by Enriching the Differentially Expressed Genes

Liu

Zhang

et al. 2018

Rev. Bras. Cienc. Avic.

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“…To the effective limit of these screening methods for detecting mRNA (approximately one or two copies per cell), this clone was not detectably expressed in any T-cell line or in thymus. Since B and T cells express an estimated 98% of their genes in common (29) isolate and characterize murine B lymphocytes and their precursors (30). B-cell-specific clone B29 hybridized with an mRNA of 1.4 kb expressed in all B-lineage cells tested, including myeloma and hybridoma cells secreting different classes of immunoglobulin ( Fig.…”

Section: Resultsmentioning

confidence: 99%

B29: a member of the immunoglobulin gene superfamily exclusively expressed on beta-lineage cells.

Hermanson

Eisenberg

Kincade

et al. 1988

Proc. Natl. Acad. Sci. U.S.A.

171

100

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A number of the glycoproteins identified on the surfaces of cells of the immune response belong to the immunoglobulin superfamily. We have isolated and characterized cDNA clones and the complete genomic gene encoding a B-cell-specific member of the immunoglobulin superfamily called "B29." This isolate is expressed at all stages in B-cell development beginning with the earliest precursor B cells undergoing immunoglobulin heavy chain gene diversity region

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“…This disagrees with earlier studies, particularly in mice, which demonstrated that fetal and adult lymphoid precursors are distinct in terms of morphological characteristics, expression of surface markers and TdT, and antigen receptor diversity. [38][39][40] These characteristics appear to be fixed. For instance, fetal B cells propagated on an adult bone marrow stromal layer retained their fetal characteristics and did not develop into an adult-like population.…”

Section: Recapitulation Of Fetal Ontogeny As a Mechanism Of Immune Rementioning

confidence: 99%

Reconstitution of the B cell repertoire after bone marrow transplantation does not recapitulate human fetal development

Raaphorst

1999

Bone Marrow Transplant

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Summary:Immune reconstitution during bone marrow transplantation has been proposed to produce a fetal-type immune system. This characteristic may contribute to the relative immunodeficiency that occurs in the early post-transplant period. This review reappraises recent studies of immunoglobulin heavy chain genes produced by the recovering immune system. Comparison of these genes to those that are generated by fetal and adult B cells, demonstrates that there is no evidence to support the conclusion that adult lymphocytes in the graft reverse to a fetal stage of differentiation. In terms of lymphocyte diversity, the inadequacy of the recovering immune system is more likely to be explained by a combination of other factors -such as the delayed occurrence of somatic hypermutation and class switching, and clonal dominance. Keywords: immune reconstitution; immunoglobulin; repertoire development; CDR3; diversity; fetus The purpose of stemcell/bone marrow transplantation (BMT) is transfer of a functional immune system to an immunocompromised recipient. The early period after BMT, however, is characterized by cellular and humoral immunodeficiency which can last for months to years. Whereas components of non-specific immunity (granulocytes, monocytes/macrophages and NK cells) recover within 2-6 months, functional recovery of B and T lymphocytes can take up to 2 years or longer. 1 Many factors contributing to this slow recovery have been identified, such as the immunosuppressive effect of high-dose radio/chemotherapy, the effect of graft-versus-host disease (GVHD), treatment of GVHD by immunosuppressants and decreased thymic function in older patients.Serological studies and analysis of cell surface marker expression showed that reconstitution of humoral immunocompetence follows patterns previously described in neonates. [2][3][4][5][6] Antibodies against protein and conjugated polysaccharide antigens predate immune responses against carboCorrespondence: Dr FM Raaphorst,

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Experimental Models for Understanding B Lymphocyte Formation

Cited by 120 publications

References 462 publications

The Gene Ontology Differs in Bursa of Fabricius Between Two Breeds of Ducks Post Hatching by Enriching the Differentially Expressed Genes

The Gene Ontology Differs in Bursa of Fabricius Between Two Breeds of Ducks Post Hatching by Enriching the Differentially Expressed Genes

B29: a member of the immunoglobulin gene superfamily exclusively expressed on beta-lineage cells.

Reconstitution of the B cell repertoire after bone marrow transplantation does not recapitulate human fetal development

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