Experimental model of invasion and metastasis by orthotopic transplantation of oral squamous and adenoid cystic carcinomas into the tongue of nude mice

Transcutaneous Carbon Dioxide Induces Mitochondrial Apoptosis and Suppresses Metastasis of Oral Squamous Cell Carcinoma In Vivo

“…SCCs grow rapidly and readily metastasize to the regional lymph nodes [1]. Lymph node metastasis is a well-established negative prognostic indicator in the treatment of squamous cell carcinoma of the head and neck [2].…”

Establishment of an animal model of spontaneous cervical lymph node metastasis of laryngeal squamous cell carcinoma and obtaining laryngocarcinoma cells with high metastatic potential

“…A similar approach for investigating the biological characteristics of tumors has only been reported in studies of oral squamous cell carcinoma. Umeda et al [12] established a model of lymph node metastasis of oral cancer by inoculating tumor cells and tissues into the tongues of nude mice. The survival rate of tumor cells was 50%-83%, and the rate of lymph node metastasis was only 13%-40%.…”

Immunocompromised and immunocompetent mouse models for head and neck squamous cell carcinoma

“… 35 , 36 Another experimental model of invasion and metastasis was built by orthotopic transplantation of HSC-2, HSC-3, and HSC-3 cell lines into tongue of nude mice. 37 …”

“…The rate of invasion and metastasis is very uncertain and different, changing from very low to markedly high due to dissimilar transplantation methods, hosts, and transplantation site, though invasion or metastasis was observed in most cases. 33 , 34 , 37 One hundred and six malignant human tumor cell lines including 11 different tumor cell lines were studied in 1,045 nude mice, with only 14 (1.3%) instances of metastasis. 52 In addition, some studies have showed that many compounds with significant antitumor effects in immunocompromised models do not work in human beings.…”