Experimental Method for Studying Growth Rates of Particles in Aqueous Media

Higuchi, William I.; Lau, P.K.

doi:10.1002/jps.2600511116

Cited by 15 publications

(1 citation statement)

References 5 publications

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“…A higher correlation coefficient obtained from the analysis of the amount of the drug released versus the square root of time indicated that the release followed the Higuchi (Higuchi, 1962) kinetic model ( Table 2 ). 24 …”

Section: Resultsmentioning

confidence: 99%

Preparation and characterization of pH-sensitive nanoparticles of budesonide for the treatment of ulcerative colitis

Qian¹

2018

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ObjectiveThe aim of this study was to develop pH sensitive nanoparticles of budesonide for the treatment of ulcerative colitis.MethodsThe NPs system was characterized by the transmission electron microscopy (TEM), particle size, drug loading and encapsulation efficiency. In addition, in vitro drug release prop-erties and pharmacokinetics were also investigated in detail. The optimized formulation was examined for its in-vivo targeting potential using 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in a rat model.ResultsDynamic light-scattering results showed that the particle size of budesonide-Eudragit S100/poly(lactic-co-glycolic acid) nanoparticles was around 110.5 nm, with a polydispersity index of 0.098. Transmission electron microscopy images showed that BUD-ES100/PLGA NPs were spherical with uniform size and relatively smooth surfaces. In vitro release showed that BUD-ES100/PLGA NPs required minimal release of drugs during its transit in the stomach and the upper small intestine to ensure that a maximum dose reached the colon. After the pharma-codynamic treatment, the myeloperoxidase value of BUD-ES100/PLGA NPs was close to the normal group. The histopathological examination of rectum showed that no sign of damages such as epithelial necrosis and sloughing epithelial cells was detected.ConclusionOur findings suggested that BUD-ES100/PLGA NPs were a promising alternative to single pH-dependent systems for colitis therapy.

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Section: Resultsmentioning

confidence: 99%