Experimental measurement and modeling of quinizarin solubility in pressurized hot water

Vázquez, M.F. Barrera; Gañán, Nicolás Alberto; Comini, Laura R.; Martini, Raquel E.; Bottini, Susana B.; Andreatta, Alfonsina E.

doi:10.1016/j.supflu.2016.12.020

Cited by 3 publications

(4 citation statements)

References 57 publications

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“…On the other hand, extrapolation of these models to temperatures or pressures outside the regression region is not guaranteed, since binary interaction parameters obtained from the regression of solid−gas equilibria data do not seem to follow any general trend. 159 Various optimization approaches are used for modeling the solubility of substances of interest. For instance, genetic algorithms have been utilized to calculate the solubility of solid solutes in pressurized fluids.…”

Section: System Investigatedmentioning

confidence: 99%

“…Employing thermodynamic models based on cubic equations of state in combination with appropriate mixing rules enables the prediction of thermodynamic data over large ranges of temperature and pressure. On the other hand, extrapolation of these models to temperatures or pressures outside the regression region is not guaranteed, since binary interaction parameters obtained from the regression of solid–gas equilibria data do not seem to follow any general trend . Various optimization approaches are used for modeling the solubility of substances of interest.…”

Section: Modelingmentioning

confidence: 99%

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Solubility of Solids in Sub- and Supercritical Fluids: A Review 2010–2017

2017

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A review of the solubility data for solids in sub- and supercritical fluids published in the literature between 2010 and 2017 is presented, including the pressure and temperature ranges and correlation methods. Compounds are categorized into the following groups: pharmaceutical, biological, aromatic, nonaromatic, organometallic, and polymer. The most commonly used solvent is supercritical CO2; some data have also been published for other solvents, such as argon, propane, and fluorinated hydrocarbons.

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Section: System Investigatedmentioning

confidence: 99%

Section: Modelingmentioning

confidence: 99%

Solubility of Solids in Sub- and Supercritical Fluids: A Review 2010–2017

2017

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“…In the case of the binary interaction parameters between the ketone group and the olefinic groups, not available in the revised matrix, they were taken from our own previous adjustments [38]. The carbonyl groups in thymoquinone were represented using the cyC=O group previously defined by Barrera et al [41].…”

Section: Gc-eos Modelmentioning

confidence: 99%

Solubility of three natural compounds with insecticidal activity in supercritical carbon dioxide: Experimental measurements and predictive modeling with the GC-EoS

Mazzei

Ortega

Andreatta

et al. 2019

Fluid Phase Equilibria

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In this work, the solubility of thymoquinone, R-(+)-pulegone and 1-octen-3-ol in supercritical CO 2 is determined in a range of conditions typical of supercritical fluid processes such as extraction, fractionation and impregnation. These compounds were selected based in their insecticidal activity which may enable to apply them as biopesticides. Solubility was measured using a semicontinuos method in the temperature range of 45-65°C and pressure of 8-12 MPa, at a CO 2 flowrate of 0.05-0.10 g/min, which was verified to be low enough to ensure saturation. Solubilities were predicted using the Group Contribution Equation of State (GC-EoS) and compared to the experimental results, with a good agreement. Consistency of the data was tested using the density-based Chrastil equation.

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“…One of the biggest challenges of PDT is the choice of the most suitable photosensitizer, which essential characteristics such as biological affinity, biodistribution and minimum photodynamic potential for application [15]. Quinizarin, (QZ) (1,4 dihydroxyanthraquinone), an anthraquinone derivative compound, shows secondary biological activities characteristics as anti-inflammatory, antioxidant, antibacterial action [19][20][21], and high potential as photosensitizing compounds [22] showing high-density planar and quinoid conjugated aromatic groups electronics, which may contribute to the generation of reactive oxygen species (ROS), [23][24][25][26], with a high potential as photosensitizing compounds from a PDT perspective [22].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Photodynamic Therapy as a New Therapeutic Approach Using Quinizarin-Loaded Nanocapsules: In Vitro Cytotoxicity, Permeation in 3D Bioprinted Skin Equivalent and In Vitro Cytokines Modulation

do Amaral,

Amantino,

Atanasov

et al. 2024

Preprint

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Skin inflammation associated with chronic diseases has the direct action of keratinocytes in its immunopathogenesis, leading to a series of immune responses. However, there are still no highly targeted treatments, and the development of more specific therapies is highly desirable. In the present work, nanocapsules containing quinizarin (QZ/NC) were developed, evaluating their act in a model of the keratinocytes inflammatory process in vitro with the action of Photodynamic Therapy, analyzing the permeation in a 3D skin model. Physicochemical, stability, cytotoxicity and permeation analyses of the nanomaterials were carried out. The nanocapsules showed desirable physicochemical characteristics and were stable during the analysis period, without spectroscopic modifications. The cell viability test carried out showed no cytotoxicity at the lowest QZ/NC concentrations. The permeation and cellular uptake studies showed the permeation of QZ/NC in 3D skin models and the intracellular incorporation and internalization of the drug, enhancing its action in the drug delivery technique. Promising results were presented using the model developed to induce the inflammatory process in vitro and applying the synthesized nanomaterial in conjunction with PDT, where a decrease in the levels of cytokines analyzed was observed, representing a possible new therapeutic approach for inflammatory skin diseases.

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Experimental measurement and modeling of quinizarin solubility in pressurized hot water

Cited by 3 publications

References 57 publications

Solubility of Solids in Sub- and Supercritical Fluids: A Review 2010–2017

Solubility of Solids in Sub- and Supercritical Fluids: A Review 2010–2017

Solubility of three natural compounds with insecticidal activity in supercritical carbon dioxide: Experimental measurements and predictive modeling with the GC-EoS

Evaluation of Photodynamic Therapy as a New Therapeutic Approach Using Quinizarin-Loaded Nanocapsules: In Vitro Cytotoxicity, Permeation in 3D Bioprinted Skin Equivalent and In Vitro Cytokines Modulation

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