Experimental Lymphatic Obstruction and Fat Absorption in the Rabbit

Abstract

Using a previously published procedure of experimental abdominal lymphatic duct obstruction, we were unable to confirm increased faecal fat excretion after the operation. Nevertheless, the completeness of the obstruction and the huge dilatation of the lymph ducts of the villi have been verified. A spontaneous seasonal variation of faecal fat excretion has been observed in the rabbit with a maximum in October and November.

Thoracic Duct Narrowing—Innovative Technique Restraining Weight Gain in Rats

“…7 and 8), refuted the possibility of fast plasma lipid clearance as possible explanation for lack of plasma lipid difference. These findings, although opposing the preliminary premise, come in line with past animal studies that showed no difference in plasma lipids after TD ligation [18,19]. Human studies on the contrary, did show such difference after TD ligation [15,16].…”

“…Identifying the Bend-point^of weight gain restraint and unable to find the exact mechanism for this reduction to occur, we are left with intriguing questions. Our study did not look into lipid feces analysis although former studies failed to show such changes under thoracic duct ligation [18,22]. Identification of congested lymphatics (Fig.…”

“…Animal studies failed to show reduction in fat consumption and fecal excretion after TD ligation [18,19]. Contradicting evidence anecdotally reported weight reduction after lymphatic drainage in rats [9,20,21] as opposed to no weight reduction in sheep with TD side fistula [22].…”