Experimental leishmania major infection in mice: The role of IL-10

Châtelain, R; Coffman, Robert L.

doi:10.1016/s0923-1811(98)84049-8

Cited by 22 publications

(23 citation statements)

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“…28,29 IFN-g is important in mediating the Th1 response, 30 whereas IL-10 and its receptor have been implicated in the Th2 response, although its specific involvement in the response to L. major is controversial. 31,32 IL-10 has recently been shown to be required for the persistence of parasites in mice after cure of visible disease. 33 Although the IL-10Ra chain gene localises to proximal chromosome 9, it is not included in the lmr2 congenic interval.…”

Section: Discussionmentioning

confidence: 99%

Leishmaniasis host response loci (lmr1–3) modify disease severity through a Th1/Th2-independent pathway

et al. 2003

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Section: Discussionmentioning

confidence: 99%

Leishmaniasis host response loci (lmr1–3) modify disease severity through a Th1/Th2-independent pathway

et al. 2003

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“…These data might be an apparent contradiction to the fact that these animals controlled the infection. However, Chatelain et al [24] reported that L. major susceptible mice treated with mAb to IL-10 did not control the infection. Moreover, the increase in IL-10 production by the cells obtained from mAb-treated animals may explain why these animals, even producing high levels of IFN-+ , had a reduction in iNOS activity in the macrophages, since there is evidence that IL-10 inhibits the iNOS induction in this cell type [25].…”

Section: Discussionmentioning

confidence: 99%

TNF‐α mediates the induction of nitric oxide synthase in macrophages but not in neutrophils in experimental cutaneous leishmaniasis

et al. 2003

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Leishmania major infection in C57BL/6 mice is controlled by the activation of a Th1 response and nitric oxide (NO) production by macrophages. TNF- § is considered one of the most important cytokines involved in this response. In the present study, we investigated the expression of nitric oxide synthase (iNOS) in the inflammatory cells present in the lesion and draining lymph nodes, and the cytokine production by lymph node cells in animals treated with anti-TNF- § . Our results demonstrated that mice treated with anti-TNF- § presented an increase in the number of parasites and the size of lesion, but they were able to control the infection. The increase in the lesion size correlated to the reduction of iNOS activity in the draining lymph nodes. Furthermore, the anti-TNF- § treatment also reduced the expression of iNOS in the macrophages, but did not affect the iNOS expression in the neutrophils. The anti-TNF- § mAb did not reduce the iNOS expression in IFN-+ -stimulated L. major infected neutrophils in vitro. Anti-TNF- § mAb treatment caused an increase in the production of IFN-+ and IL-10 by the lymph node cells from infected mice. Consequently, these results suggest that neutrophils do not respond to anti-TNF- § treatment and might be a source of NO to control L. major infection under these experimental conditions.

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“…Protective immunity would be associated with Th1 cells that produce INF-␥ and IL-2, whereas Th2 cells, which produce immunosuppressive IL-4 and IL-10, could facilitate the survival and dissemination of the parasite generating tissue damage and the appearance of the disease. Recent evidence [61][62][63] suggests an important role for IL-10, but not for IL-4 in the Th2 response. However, as has been proposed by others, [64][65][66][67] we analyzed IL-4 and IFN-␥ as indicators of Th2 and Th1, respectively.…”

Section: Discussionmentioning

confidence: 99%

Differentiation of entamoeba histolytica/entamoeba dispar by PCR and their correlation with humoral and cellular immunity in individuals with clinical variants of amoebiasis.

Sánchez-Guillén¹,

Pérez-Fuentes

Salgado-Rosas

et al. 2002

The American Journal of Tropical Medicine and Hygiene

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Abstract. To correlate a particular state of immunity with Entamoeba spp., we used colorimetric PCR to differentiate E. histolytica from E. dispar in individuals with amoebiasis and to associate its presence with the clinical profile, including humoral and cellular immune responses to E. histolytica. Our results showed high levels of antibody in acute amoebiasis and elevation of IL-4 production, a cytokine related to Th2 profile, associated with E. histolytica. In chronic amoebiasis, even with anti-E. histolytica seropositivity, intestinal symptoms were associated with E. dispar in all the cases, without differences in level of antibodies, BTI, CD4+/CD8+ ratio, INF-␥, and IL-4. Among asymptomatic carriers, E. dispar was more frequently found; however, identification of E. histolytica in two asymptomatic carriers associated with high levels of INF-␥, a cytokine related to Th1 profile, demonstrate the importance of making specific diagnosis of Entamoeba spp., to establish the clinical and epidemiological behavior in both intestinal and extra-intestinal amoebiasis.

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Experimental leishmania major infection in mice: The role of IL-10

Cited by 22 publications

References 0 publications

Leishmaniasis host response loci (lmr1–3) modify disease severity through a Th1/Th2-independent pathway

Leishmaniasis host response loci (lmr1–3) modify disease severity through a Th1/Th2-independent pathway

TNF‐α mediates the induction of nitric oxide synthase in macrophages but not in neutrophils in experimental cutaneous leishmaniasis

Differentiation of entamoeba histolytica/entamoeba dispar by PCR and their correlation with humoral and cellular immunity in individuals with clinical variants of amoebiasis.

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