Experimental irritant contact dermatitis due to cumulative epicutaneous exposure to sodium lauryl sulphate and toluene: single and concurrent application

Wigger‐Alberti, W.; Krebs, A; Elsner, Peter

doi:10.1046/j.1365-2133.2000.03710.x

Cited by 23 publications

(29 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…in fish and fish products, cheese, meat and fermented foods [2]. We could demonstrate that sequential ('tandem') application by using the 'tandem repeated irritation test' [14][15][16][17] of different irritants modifies the cutaneous response in contrast to repeated exposure to the specific irritant alone.…”

Section: Discussionmentioning

confidence: 99%

“…Irritant contact dermatitis studies usually focused on different effects of single irritant exposures [3][4][5][6], in particular sodium lauryl sulphate (SLS) [6][7][8][9][10][11][12][13]. Recently, we have been able to demonstrate that sequential ('tandem') application of different irritants may modify the cutaneous response indicating an aggravating effect of the combination of irritants [14][15][16][17]. It has been shown that the stratum corneum (SC) pH is important for barrier-related parameters, e.g.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Additive Impairment of the Barrier Function and Irritation by Biogenic Amines and Sodium Lauryl Sulphate: A Controlled in vivo Tandem Irritation Study

Fluhr

Kelterer

Fuchs

et al. 2005

Skin Pharmacol Physiol

Self Cite

View full text Add to dashboard Cite

Biogenic amines are potential irritants e.g. in fish-, meat-, milk- and egg-processing professions like cooks, butchers and bakers. The aim of this study was to test the irritative and barrier-disrupting properties of the biogenic amines ammonium hydroxide (AM), dimethylamine (DMA) and trimethylamine (TMA). A repeated sequential irritation of 30 min twice per day was performed over a total of 4 days (tandem repeated irritation test) on the back of 20 healthy volunteers of both sexes with AM, DMA, TMA and sodium lauryl sulphate (SLS). The epidermal barrier function was assessed with a Tewameter TM 210, stratum corneum surface pH was measured with a Skin-pH-Meter 900, inflammation was assessed with a Chromameter CR-300 on the a* axis for redness and a visual score was recorded. All tested biogenic amines (AM, DMA and TMA) induced a barrier disruption and a pH increase paralleled with a 1-day-delayed onset of inflammatory signs. These effects were further enhanced and accelerated by a sequential application of SLS together with the biogenic amines, and inflammation occurred earlier than with the single compounds. Acetic acid (AA) in contrast did only show mild barrier disruption and no significant inflammatory signs. Our system allowed a ranking of the different compounds in their irritative potential in the tandem irritation with SLS: SLS > NaOH > TMA > AA > AM > DMA. The results are suggestive that in the food-processing industry the simultaneous contact with biogenic amines and harmful detergents like SLS should be minimized.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Additive Impairment of the Barrier Function and Irritation by Biogenic Amines and Sodium Lauryl Sulphate: A Controlled in vivo Tandem Irritation Study

Fluhr

Kelterer

Fuchs

et al. 2005

Skin Pharmacol Physiol

Self Cite

View full text Add to dashboard Cite

show abstract

“…Many cleansers contain surfactants, and repeated exposure to these surfactants can cause allergic contact dermatitis (Inoue et al, 2008) and irritant contact dermatitis (Wigger-Alberti et al, 2000). Surfactants irritate the skin through several mechanisms, including interaction with keratin (Imokawa et al, 1975) and changing lipid structure and barrier function (Wihelm et al, 1994;Ananthapadmanabhan et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Topical Surfactant-Induced Pruritus: Involvement of Histamine Released from Epidermal Keratinocytes

Inami

Andoh

Sasaki

et al. 2012

J Pharmacol Exp Ther

View full text Add to dashboard Cite

Surfactants, an important component of cleansers, often cause itch in humans. Topical application of sodium laurate and Nlauroylsarcosine sodium salt to the skin of mice immediately (for 1-1.5 hours) increased scratching, and the former increased scratching again between 2 and 3 hours after application. Thus, we examined the mechanisms of sodium laurate-induced delayed scratching. Sodium laurate (0.1%-10%) increased delayed scratching and skin surface pH in a concentrationdependent manner. N-lauroylsarcosine sodium salt had no effect on these parameters, and sodium hydroxide solution did not increase delayed scratching. Sodium laurate-induced delayed scratching was markedly inhibited by the H 1 histamine receptor antagonist terfenadine, but it was not affected by mast cell deficiency. Sodium laurate application had no effect on the number of total and degranulated mast cells, and did not induce plasma extravasation or the infiltration of inflammatory cells in the skin. Sodium laurate application increased the histamine content of the epidermis, but not that of the dermis, in normal and mast cell-deficient mice. Sodium laurate application increased the ratio of 53-kDa L-histidine decarboxylase (HDC, a key enzyme for histamine production) to 74-kDa HDC in the mouse epidermis and in a human keratinocyte culture. Sodium laurate increased histamine in the human keratinocyte culture, without affecting cell viability. The present results suggest that sodium laurate induced delayed scratching at an alkaline pH through the increased production of histamine in keratinocytes, which may be due to enhanced processing of 74-kDa to 53-kDa HDC.

show abstract

“…Based on the literature, the concentrations of sodium lauryl sulfate, propylene glycol, and DMSO in the skin cream should be less than 1%, 30%, and 50%, respectively, in order to prevent dermatitis and other kinds of skin damage. [12][13][14][15][16] The optimal formulation was then prepared and further studied.…”

Section: Experimental Designmentioning

confidence: 99%

Development and Pre-clinical Study of Anti-Allergic Cream Containing Dexamethasone and Chlorpheniramine

Phạm¹,

Nguyen²

2018

tjps

View full text Add to dashboard Cite

Amaç: Bu çalışmada deney tasarımı (DoE) yöntemi kullanılarak deksametazon ve klorfeniramin içeren anti-alerjik kremlerin geliştirilmesi ve optimize edilmesi amaçlandı. Optimize edilen ürünün, tavşanlarda fizikokimyasal özellikleri ve in vivo terapötik etkileri araştırıldı. Gereç ve Yöntemler: Kremler, Design Expert yazılımı tarafından optimize edilen basit karıştırma işlemi ile formüle edildi. Daha sonra pH, deri difüzyon profili, kısa süreli stabilite, kalitatif tayin ve yeni valide edilmiş UV-Vis spektrofotoskopi yöntemi kullanılarak ürünlerin kantitatif miktar tayini gibi özellikleri değerlendirildi. En iyi ürünlerin tavşanlarda in vivo etkinlik testi, piyasadaki Phenergan ® (prometazin %2) ile karşılaştırıldı. Bulgular: Hem deksametazon hem de klorfeniramin miktarını eşzamanlı olarak belirlemek için UV-Vis yöntemi başarıyla geliştirildi ve valide edildi. DoE yöntemini kullanarak, deksametazonun salım profilinin, sodyum lauril sülfat, propilen glikol ve DMSO miktarına bağlı olduğu açıktı. Oysa klorfeniramin salınım modelini sadece DMSO etkiliyordu. Ayrıca, en iyi formülasyon yazılım tarafından optimize edildi. Ürün, deksametazon ve klorfeniramin için sırasıyla pH'de (5.7±0.1), 10 gün içinde kısa süreli stabilite, 40.4 dakika sonra %20.47±1.25 ve %4.92±0.42'lik deri difüzyon profilleri için kabul edilebilir parametreler gösterdi. Buna ek olarak, ürün, deney hayvanlarında gözlemlenebilir bir enflamatuvar tepki göstermedi. Ayrıca, satılan ürüne kıyasla 2 kat daha iyi anti-alerjik etkinlik (yani, geri kazanım süresinde 43.4 dakika ile karşılaştırıldığında 27.2 dakika) gösterdi. Sonuç: Deksametazon ve klorfeniramin içeren anti-alerjik kremin geliştirilmesi ve optimize edilmesi konusunda başarılı olduk. En iyi ürün gerekli tüm parametreleri sağlamıştır. İlginç bir şekilde, ürünümüz Phenergan ® 'dan daha yüksek etkililik gösterdi. Bu sonuçlar, klinik araştırmalarda ileri çalışmalar için bir zemin olabilir. Anahtar kelimeler: Deksametazon, klorfeniramin, alerjik, deney tasarımı, in vivo çalışma Objectives: In this study, we aimed to develop and optimize an anti-allergic cream containing dexamethasone and chlorpheniramine using the design of experiments (DoE) method. The optimized product was investigated for its physicochemical properties and in vivo therapeutic effects in rabbits. Materials and Methods:The creams were formulated using the simple mixing process, which was optimized by the Design Expert software. The products were then evaluated the properties such as pH, skin diffusion profile, short-term stability, qualitative, and assay, using the newly validated UV-Vis spectrophotoscopy quantitative method. In vivo efficacy tests in rabbits of the best products were compared with the marketed Phenergan ® (promethazine 2%). Results: The UV-Vis method used to simultaneously determine the amount of both dexamethasone and chlorpheniramine was successfully developed and validated. Using the DoE method, it was clear that the release profile of dexamethasone depended on the amount of sodium lauryl sulfate, propyl...

show abstract

Experimental irritant contact dermatitis due to cumulative epicutaneous exposure to sodium lauryl sulphate and toluene: single and concurrent application

Cited by 23 publications

References 0 publications

Additive Impairment of the Barrier Function and Irritation by Biogenic Amines and Sodium Lauryl Sulphate: A Controlled in vivo Tandem Irritation Study

Additive Impairment of the Barrier Function and Irritation by Biogenic Amines and Sodium Lauryl Sulphate: A Controlled in vivo Tandem Irritation Study

Topical Surfactant-Induced Pruritus: Involvement of Histamine Released from Epidermal Keratinocytes

Development and Pre-clinical Study of Anti-Allergic Cream Containing Dexamethasone and Chlorpheniramine

Contact Info

Product

Resources

About