Experimental investigation of the action of pulsed electrical discharges in liquids on biological objects

Efremov, N. M.; Adamiak, B.Yu.; Blochin, V.I.; Dadashev, S.Ja.; Дмитриев, К. И.; Semjonov, V.N.; Levashov, V. F.; Jusbashev, V.F.

doi:10.1109/27.842908

Cited by 37 publications

(17 citation statements)

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“…A number of workers have reported on a range of experimental approaches and the general effectiveness of electrical discharges in liquids in terms of their sterilization, disinfectant, and bactericidal properties has been well established [17]- [21]. High-energy electrical breakdown phenomena in electrolyte solutions have been reported [22], [23], including some features similar to those observed by us, but the powers dissipated were significantly higher than in our investigation.…”

supporting

confidence: 59%

Plasma characteristics of repetitively-pulsed electrical discharges in saline solutions used for surgical procedures

Woloszko

Stalder²,

Brown

2002

IEEE Trans. Plasma Sci.

141

102

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Abstract-Characteristics of plasmas formed by repetitively-pulsed electrical discharges in sodium chloride and barium chloride saline solutions are reported. Spectroscopic observations in conjunction with an analysis of the voltage and current behavior of the discharge lead to a model in which the liquid is vaporized and ionized to form a plasma containing excited water fragments H* and OH* as well as ions and neutrals from the salt. For typical conditions under which plasma is formed, the plasma density is estimated to be of order 10 12 cm 3 and the electron temperature about 4 eV.Index Terms-Breakdown in liquids, dissociative excitation, electrical breakdown, electrosurgery, plasma discharges, plasma spectroscopy, surgical tools.

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supporting

confidence: 59%

Plasma characteristics of repetitively-pulsed electrical discharges in saline solutions used for surgical procedures

Woloszko

Stalder²,

Brown

2002

IEEE Trans. Plasma Sci.

141

102

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“…The electrode was therefore separated from the fluid. This technique has also been used in large-scale PEF equipment [72][73][74][75]. It would be logical to think that such an approach should be copied in future microtechnological structures, for example by applying dedicated coatings [76].…”

Section: Electrode Propertiesmentioning

confidence: 99%

Electroporation of cells in microfluidic devices: a review

et al. 2006

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In recent years, several publications on microfluidic devices have focused on the process of electroporation, which results in the poration of the biological cell membrane. The devices involved are designed for cell analysis, transfection or pasteurization. The high electric field strengths needed are induced by placing the electrodes in close proximity or by creating a constriction between the electrodes, which focuses the electric field. Detection is usually achieved through fluorescent labeling or by measuring impedance. So far, most of these devices have only concerned themselves solely with the electroporation process, but integration with separation and detection processes is expected in the near future. In particular, single-cell content analysis is expected to add further value to the concept of the microfluidic chip. Furthermore, if advanced pulse schemes are employed, such microdevices can also enhance research into intracellular electroporation.

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“…Lethal threshold concentrations for Bacillus cereus, Bacillus megaterium, and E. coli were determined to be 0.12, 0.19, and 0.19 mg L À1 , respectively, wherein 1 mg L À1 corresponds to 1 ppm of ozone. 1 Efremov et al [13] discussed reaction rate constants for production and destruction of ozone formed during plasma generation. They conjectured that the antiseptic property of the excited dry air flowing out of a discharge chamber was determined by its ozone concentration and demonstrated that exposing microorganism concentrations to discharge-excited air, even for a short while, substantially reduced their amount.…”

Section: Introductionmentioning

confidence: 99%

Examining the Role of Ozone in Surface Plasma Sterilization Using Dielectric Barrier Discharge (DBD) Plasma

Mastanaiah

Banerjee

Johnson

et al. 2013

Plasma Processes & Polymers

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Dielectric barrier discharge (DBD) devices are known ozone generators. Authors have previously demonstrated a DBD surface plasma source, operating in air at atmospheric pressure, to achieve killing of vegetative cells in 2-3 min and sterilization in 20 min (bacterial spores). The aim of this paper is to examine the role of the ozone in surface DBD plasma sterilization. The role of ozone in plasma killing is examined by a) characterizing the rate of production/decay of ozone during DBD plasma generation, b) studying the effect of exposing bacteria (Escherichia coli) solely to the ozone thus produced. Our results indicate that while ozone plays a major role, the energy flux delivered to the electrodes is also crucial in the process of plasma sterilization.

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Experimental investigation of the action of pulsed electrical discharges in liquids on biological objects

Cited by 37 publications

References 0 publications

Plasma characteristics of repetitively-pulsed electrical discharges in saline solutions used for surgical procedures

Plasma characteristics of repetitively-pulsed electrical discharges in saline solutions used for surgical procedures

Electroporation of cells in microfluidic devices: a review

Examining the Role of Ozone in Surface Plasma Sterilization Using Dielectric Barrier Discharge (DBD) Plasma

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