Experimental investigation of intravascular OCT for imaging of intracranial aneurysms

Hoffmann, Thomas Sören; Glaßer, Sylvia; Boese, Axel; Brandstädter, K.; Kalinski, Thomas; Beuing, Oliver; Skalej, Martin

doi:10.1007/s11548-015-1275-1

Cited by 20 publications

(19 citation statements)

References 22 publications

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“…While the model generation is simpler, the information about the vessel wall tissue is very limited. However, new imaging techniques like optical coherence tomography might allow detailed vessel wall imaging in the future and make simulations with patient-specific wall composition possible [13].…”

Section: Discussionmentioning

confidence: 99%

Complex wall modeling for hemodynamic simulations of intracranial aneurysms based on histologic images

et al. 2021

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Purpose For the evaluation and rupture risk assessment of intracranial aneurysms, clinical, morphological and hemodynamic parameters are analyzed. The reliability of intracranial hemodynamic simulations strongly depends on the underlying models. Due to the missing information about the intracranial vessel wall, the patient-specific wall thickness is often neglected as well as the specific physiological and pathological properties of the vessel wall. Methods In this work, we present a model for structural simulations with patient-specific wall thickness including different tissue types based on postmortem histologic image data. Images of histologic 2D slices from intracranial aneurysms were manually segmented in nine tissue classes. After virtual inflation, they were combined into 3D models. This approach yields multiple 3D models of the inner and outer wall and different tissue parts as a prerequisite for subsequent simulations. Result We presented a pipeline to generate 3D models of aneurysms with respect to the different tissue textures occurring in the wall. First experiments show that including the variance of the tissue in the structural simulation affect the simulation result. Especially at the interfaces between neighboring tissue classes, the larger influence of stiffer components on the stability equilibrium became obvious. Conclusion The presented approach enables the creation of a geometric model with differentiated wall tissue. This information can be used for different applications, like hemodynamic simulations, to increase the modeling accuracy.

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Section: Discussionmentioning

confidence: 99%

Complex wall modeling for hemodynamic simulations of intracranial aneurysms based on histologic images

et al. 2021

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“…There have been a few clinical case reports of intravascular OCT in neurointerventional surgery demonstrating the ability to characterize treatment of intracranial atherosclerotic disease, 31 vascular remodeling pursuant to stent-assisted aneurysm coiling, 32 and delineating pathophysiology traumatic aneurysms of the cervical carotid 33 . However, intravascular OCT as applied to neurointerventional surgery has largely been limited to studying neurovascular devices in preclinical peripheral vascular models, human cadavers with special preparation, 28,34 or clinical cases involving the extracranial circulation. This is due to the OCT catheter profile and stiffness that are both much higher than devices intended for the tortuous cerebral vasculature.…”

Section: Historical Review Of Oct In Neurointerventional Surgerymentioning

confidence: 99%

“…Detection of single-scattered near-infrared light is limited to a maximum tissue penetration depth of 3 mm, which may hinder complete characterization of intracranial atherosclerotic disease or aneurysm wall structure through the parent vessel wall. 34 Image quality requires sufficient blood displacement, and if not obtained, blood (or erythrocyte-rich clot) can result in light attenuation and subsequent image degradation. Other well-known artifacts have been previously described, but in general are found to be present only in few images of the vessel segment, are readily identified, and do not impact overall clinical interpretation.…”

Section: Applications Of High-frequency-oct For Neurointerventional Surgerymentioning

confidence: 99%

Intravascular Optical Coherence Tomography for Neurointerventional Surgery

Gounis

Ughi

Marosfői

et al. 2019

Stroke

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“…Intravascular optical coherence tomography (OCT) of the vessel walls was performed with the Terumo Lunawave system (Terumo Corporation, Tokyo, Japan), which includes an OCT catheter (Fastview, Terumo Corporation, Tokyo, Japan) with a distal diameter of 2.6 F. The axial spatial resolution is below 20 µm with good soft tissue contrast and real-time visualization (158 fps). A slice thickness of 127 µm was reached with a radial resolution of 13 µm [11].…”

Section: Image Acquisitionmentioning

confidence: 99%

Fluid-structure interaction in intracranial vessel walls: The role of patient-specific wall thickness

Voß¹,

Saalfeld

Hoffmann

et al. 2018

Current Directions in Biomedical Engineering

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Computational Fluid Dynamics studies try to support physicians during therapy planning of intracranial aneurysms. However, multiple assumptions (e.g. rigid vessel walls) are required leading to a sparse acceptance of numerical approaches within the medical community. This study incorporates multiple fluid-structural simulations for an intracranial basilar artery bifurcation. Based on a patient-specific dataset, which was acquired using optical coherence tomography, minimum, mean, maximum, and diameter-dependent thicknesses were generated and compared w.r.t. hemodynamic and wall stress parameters. The comparison of different wall thickness models revealed a strong variability among the analyzed parameters depending on the corresponding assumption. Using the patient-specific configuration as a reference, constant thicknesses lead to differences of up to 100 % in the mean wall stresses. Even the diameter-dependent thickness results in deviations of 32 %, demonstrating the wide variability of computational predictions due to inaccurate assumptions. The findings of this study highlight the importance of geometry reconstruction including accurate wall thickness reproduction for fluid-structure simulations. Patient-specific wall thickness seems to be out of alternatives regarding the realistic prediction of wall stress distributions.

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Experimental investigation of intravascular OCT for imaging of intracranial aneurysms

Abstract: Intravascular OCT provides new possibilities for diagnosis and rupture assessment of IAs. However, currently used imaging system parameters have to be adapted and new catheter techniques have to be developed for a complete assessment of the morphology of IAs.

Cited by 20 publications

References 22 publications

Complex wall modeling for hemodynamic simulations of intracranial aneurysms based on histologic images

Complex wall modeling for hemodynamic simulations of intracranial aneurysms based on histologic images

Intravascular Optical Coherence Tomography for Neurointerventional Surgery

Fluid-structure interaction in intracranial vessel walls: The role of patient-specific wall thickness

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