Nickel-based alloy can be found in different industrial applications especially in aircraft engines and hot end components of various types of gas turbines with its high strength, strong corrosion resistance and excellent thermal fatigue properties and thermal stability compared to conventional materials. However, nickel-based alloy is one of the extremely difficult-to-cut materials. During the machining process, the interaction between the tool and the workpiece causes severe plastic deformation and intense friction at the tool-workpiece interface. Because of the increasing demands in industries, any improvement of conventional machining processes or any other deployment of additional technique is directly related to higher productivity.Thermal-assisted machining (TAM) has become an effective alternative to the conventional machining of these difficult-to-cut materials. Various types of heating methods and the beneficial effects on machining of nickel-based alloys are discussed in this chapter. Finally, TAM was proven as an efficient technique to increase the machinability of nickel-based alloys in terms of tool life, surface roughness and cutting force.