Experimental Intersexuality: The Production of Feminized Male Rats by Antenatal Treatment With Estrogens

Greene, R. R.; Burrill, M. W.; Ivy, A. C.

doi:10.1126/science.88.2275.130-a

Cited by 50 publications

(9 citation statements)

References 3 publications

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“…Shortly after birth, the vaginal stratified cuboidal epithelium replaces the simple columnar epithelium of the term inal portion of the uterus masculinus. A similar replacement of Mullerian epithelium by epithelium of certain uro genital sinus origin has been reported to occur during the development of the female vagina in most mammalian species [13,18,11,16,4,35,43,2].…”

Section: Discussionmentioning

confidence: 93%

The Gross and Microscopic Anatomy of the Uterus Masculinus of Tree Shrews

Alcala¹,

Conaway²

1968

IJFP

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Section: Discussionmentioning

confidence: 93%

The Gross and Microscopic Anatomy of the Uterus Masculinus of Tree Shrews

Alcala¹,

Conaway²

1968

IJFP

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“…These mice were cryptorchid and sterile. The experimental feminizations of male mice first carried out in 1938 by Green et al [16] with estradiol in gravid rodents are still the most unique of their kind. Later investigators treated gravid rats on the 13th day of gestation with estradiol and achieved cryptorchidism in all male issue.…”

Section: Epididymis In Experimentally Induced Cryptorchidismmentioning

confidence: 99%

Pathogenesis and treatment of undescended testes

Hadžiselimović¹

1982

Eur J Pediatr

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Impaired intrauterine gonadotropin secretion was the cause of cryptorchidism in 78% of cryptorchid boys studied. On the one hand, this impairment implied the underdevelopment of the epididymis and thus the cryptorchid state of the gonad. On the other hand, the histological alterations of the testis, due to impaired gonadotropin secretion were Leydig cell atrophy and an impairment in the number of the germ cells. The secondary damage, due to the unfavorable position, started during the second year of life. To avoid this damage, early treatment is highly recommended. Hormonal treatment with GnRH is the treatment of first choice. This treatment was successful in 60% of cryptorchid boys. An additional treatment of nonresponders with low doses of hCG increased the overall success rate to 80%. Six months after treatment, 14.5% of those successfully treated suffered a relapse.

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“…The injection of oestrogenic hormone into the pregnant rat or mouse inhibits to various degrees testicular descent in the male offspring (Greene, Burrill & Ivy, 1938, 1940Raynaud, 1942). It has been suggested that the effect is mediated through the gubernacular system (Raynaud, 1958).…”

Section: Introductionmentioning

confidence: 99%

Estimation of Testosterone and Androstenedione in the Plasma and Testes of Cryptorchid Offspring of Mice Treated With Oestradiol During Pregnancy

Jean¹,

Andre²,

Cottet³

et al. 1975

Reproduction

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Summary. The injection of pregnant mice with 5 mg oestradiol dipropionate induced a high proportion of bilateral cryptorchidism in the male offspring. The ectopic testes were reduced in size and occupied one of three different positions in the abdomen: pararenal, paravesicular or inguinal. The seminal vesicles were found to be similarly reduced in size whereas the adrenals and pituitaries appeared to be unaffected. The total content of testosterone was reduced in the pararenally placed gonads but was not significantly different from that of the controls when the testes were in the inguinal region. The content of androstenedione was not significantly altered. The concentration of both hormones, however, was increased in all cases. Plasma testosterone levels were lower in all the offspring of treated mothers, especially in those with high ectopia.

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Experimental Intersexuality: The Production of Feminized Male Rats by Antenatal Treatment With Estrogens

Cited by 50 publications

References 3 publications

The Gross and Microscopic Anatomy of the Uterus Masculinus of Tree Shrews

The Gross and Microscopic Anatomy of the Uterus Masculinus of Tree Shrews

Pathogenesis and treatment of undescended testes

Estimation of Testosterone and Androstenedione in the Plasma and Testes of Cryptorchid Offspring of Mice Treated With Oestradiol During Pregnancy

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