Experimental Infestation With Human Strain Strongyloides Fülleborni in Man

Pampiglione, S; Ricciardi, M. L.

doi:10.1016/s0140-6736(72)90464-3

Cited by 14 publications

(4 citation statements)

References 6 publications

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“…Under suitable conditions, transmission may also occur in temperate regions [4–6]. Human infection with Strongyloides fuelleborni fuelleborni which also infects non-human primates, has also been reported from Southeast Asia [7] and some African countries [8–11]. Another sub-species, S .…”

Section: Introductionmentioning

confidence: 99%

A global genotyping survey of Strongyloides stercoralis and Strongyloides fuelleborni using deep amplicon sequencing

et al. 2019

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Strongyloidiasis is a neglected tropical disease caused by the human infective nematodes Strongyloides stercoralis, Strongyloides fuelleborni fuelleborni and Strongyloides fuelleborni kellyi. Previous large-scale studies exploring the genetic diversity of this important genus have focused on Southeast Asia, with a small number of isolates from the USA, Switzerland, Australia and several African countries having been genotyped. Consequently, little is known about the global distribution of geographic sub-variants of these nematodes and the genetic diversity that exists within the genus Strongyloides generally. We extracted DNA from human, dog and primate feces containing Strongyloides, collected from several countries representing all inhabited continents. Using a genotyping assay adapted for deep amplicon sequencing on the Illumina MiSeq platform, we sequenced the hyper-variable I and hyper-variable IV regions of the Strongyloides 18S rRNA gene and a fragment of the mitochondrial cytochrome c oxidase subunit 1 (cox1) gene from these specimens. We report several novel findings including unique S. stercoralis and S. fuelleborni genotypes, and the first identifications of a previously unknown S. fuelleborni infecting humans within Australia. We expand on an existing Strongyloides genotyping scheme to accommodate S. fuelleborni and these novel genotypes. In doing so, we compare our data to all 18S and cox1 sequences of S. fuelleborni and S. stercoralis available in GenBank (to our knowledge), that overlap with the sequences generated using our approach. As this analysis represents more than 1,000 sequences collected from diverse hosts and locations, representing all inhabited continents, it allows a truly global understanding of the population genetic structure of the Strongyloides species infecting humans, non-human primates, and domestic dogs.

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Section: Introductionmentioning

confidence: 99%

A global genotyping survey of Strongyloides stercoralis and Strongyloides fuelleborni using deep amplicon sequencing

et al. 2019

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“…Last, as was already mentioned, human to human transmission of S. stercoralis has been proven, however, transmission patterns of S. f. fuelleborni in human populations are rather unknown. However, experimental infection of one man by S. f. fuelleborni larvae cultured from a positive human source from Africa was followed by clinical signs (Pampiglione and Ricciardi, 1972), and its presence in people living in urban and peri-urban areas (Hira and Patel 1980) suggested the possibility of human to human transmission without the involvement of NHPs. All of the molecular data currently available comes from areas where humans and NHPs share the environment and data on further natural transmission in humans with no contact with wildlife or the forest environment are not available.…”

Section: Future Directionsmentioning

confidence: 99%

Strongyloides genotyping: a review of methods and application in public health and population genetics

Bradbury

Pafčo

Nosková

et al. 2021

International Journal for Parasitology

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“…The less-common zoonotic species, S. fuelleborni (subsp. fuelleborni ), is a non-human primate specialist (Pampiglione and Ricciardi, 1971, 1972; Hira and Patel, 1980; Nutman, 2017; Thanchomnang et al ., 2017). Its global population structure has not been extensively studied and it is not known whether the ability to infect humans varies among populations.…”

Section: Introductionmentioning

confidence: 99%

Machine learning-based analyses support the existence of species complexes for Strongyloides fuelleborni and Strongyloides stercoralis

Barratt

Sapp

2020

Parasitology

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Human strongyloidiasis is a serious disease mostly attributable to Strongyloides stercoralis and to a lesser extent Strongyloides fuelleborni, a parasite mainly of non-human primates. The role of animals as reservoirs of human-infecting Strongyloides is ill-defined, and whether dogs are a source of human infection is debated. Published multi-locus sequence typing (MLST) studies attempt to elucidate relationships between Strongyloides genotypes, hosts, and distributions, but typically examine relatively few worms, making it difficult to identify population-level trends. Combining MLST data from multiple studies is often impractical because they examine different combinations of loci, eliminating phylogeny as a means of examining these data collectively unless hundreds of specimens are excluded. A recently-described machine learning approach that facilitates clustering of MLST data may offer a solution, even for datasets that include specimens sequenced at different combinations of loci. By clustering various MLST datasets as one using this procedure, we sought to uncover associations among genotype, geography, and hosts that remained elusive when examining datasets individually. Multiple datasets comprising hundreds of S. stercoralis and S. fuelleborni individuals were combined and clustered. Our results suggest that the commonly proposed ‘two lineage’ population structure of S. stercoralis (where lineage A infects humans and dogs, lineage B only dogs) is an over-simplification. Instead, S. stercoralis seemingly represents a species complex, including two distinct populations over-represented in dogs, and other populations vastly more common in humans. A distinction between African and Asian S. fuelleborni is also supported here, emphasizing the need for further resolving these taxonomic relationships through modern investigations.

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Experimental Infestation With Human Strain Strongyloides Fülleborni in Man

Cited by 14 publications

References 6 publications

A global genotyping survey of Strongyloides stercoralis and Strongyloides fuelleborni using deep amplicon sequencing

A global genotyping survey of Strongyloides stercoralis and Strongyloides fuelleborni using deep amplicon sequencing

Strongyloides genotyping: a review of methods and application in public health and population genetics

Machine learning-based analyses support the existence of species complexes for Strongyloides fuelleborni and Strongyloides stercoralis

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