Experimental infections of mosquitoes with severe fever with thrombocytopenia syndrome virus

Liang, Shuyi; Chu, Hongliang; Guo, Xiling; Wang, Wei; Chen, Hong-Na; Zhang, Yufu; Yin, Chen; Wu, Tao; Bao, Changjun; Zhou, Minghao

doi:10.1186/s40249-017-0282-6

Cited by 5 publications

(4 citation statements)

References 18 publications

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“…In the epidemiological surveys regarding other possible vectors, it was suggested that there was no evidence of SFTSV being isolated from vectors except ticks, especially mosquitoes, captured in the human affected areas (Yu et al 2011;Xiong et al 2012). In accordance with the results, there would be little possibility that other arthropods including mosquitoes act as vectors for SFTSV transmission to animals including humans (Liang et al 2017).…”

Section: Tick Bitesmentioning

confidence: 59%

Epidemiology of SFTS in China

Katô

Saijo

2019

Severe Fever With Thrombocytopenia Syndrome

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Severe fever with thrombocytopenia syndrome (SFTS) is a novel emerging virus infection that was first found and reported in Peoples' Republic of China in 2009 and 2011, respectively. SFTS was later reported in Japan and South Korea, suggesting that SFTS is endemic to East Asian countries. Among these countries, the most SFTS cases have been reported in China. Geographically, SFTS cases have been mainly reported in rural and mountainous areas of the Eastern, Central, and NorthEastern China. So far, the number of SFTS cases has increased and the geographical distribution has expanded in China. From epidemiological studies, it was suggested that various factors including occupation, habit, tick bites, animal contact, environment, meteorological factor, demographic data, clinical symptoms, or laboratory data were associated with SFTS infection or fatal outcome. In this article, epidemiology of SFTS in China is described in detail to assess distributions over time, place, and person.

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Section: Tick Bitesmentioning

confidence: 59%

Epidemiology of SFTS in China

Katô

Saijo

2019

Severe Fever With Thrombocytopenia Syndrome

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“…Studies have shown that the related diseases transmitted by different ticks are different. The tick that transmits SFTSV are Haemaphysalis longicornis [8], which carries 4.17% to 18.75% of SFTSV [9,10].Mosquitoes do not transmit the virus [11]. In addition to tick bites, human-to-human transmission through blood or close contact has been reported [12].…”

Section: Discussionmentioning

confidence: 99%

Epidemiological Characteristics and Clinical Features of Patients With Severe Fever With Thrombocytopenia Syndrome Bunyavirus Infection

Yang¹,

Gan²,

Hu³

2020

Preprint

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ObjectivesTo investigate the epidemiological characteristics, clinical features and prognosis of patients with severe fever with thrombocytopenia syndrome bunyavirus (SFTSV) infection. MethodsThe data of 23 patients with SFTSV infection from June 2012 to July 2018 were analyzed retrospectively. ResultsAmong the 23 patients, 10 (43.5%) were male and 13 (56.5%) were female. The mean age was 58.9 ±12.1 years old. In total, 19 patients (82.6%) were farmers, and 21 cases (91.3%) occurred during the spring and summer season, especially in May and June. There were 5 cases (21.7%) with a clear history of tick bites and 2 cases (8.7%) with close contact with the patient who was feverish due to thrombocytopenia syndrome. Seventeen (73.9%) patients came from the mountainous area of southern Anhui Province. All patients had fever and thrombocytopenia. Most patients had leukocytopenia; proteinuria; urine occult blood; elevated liver enzymes; increased creatine kinase, lactate dehydrogenase and D-dimer levels; muscle soreness and clinical haemorrhage. One patient even displayed a local haematoma on the abdominal wall. Some patients had low albumin, elevated serum amylase and increased lipase. After active supportive treatment, 5 patients (21.7%) were cured, 14 patients (60.9%) were improved, 2 patients (8.7%) were discharged without recovery and 2 patients (8.7%) died of multiple organ failure. ConclusionsSFTSV infection has specific epidemiological and clinical characteristics. The disease can involve multiple organs, and its mortality rate is relatively high. Therefore, we should pay more attention to the disease to promote the early detection, timely diagnosis and accurate treatment.

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“…Using experimental infections of mosquitoes with SFTSV, Liang et al examined the role of mosquitoes in the transmission of the virus and did not detect viral replication in Culex pipiens pallens , Aedes aegypti , and Anopheles sinensis as revealed by the TaqMan quantitative real-time polymerase chain reaction (qRT-PCR) assay. Besides, the authors failed to isolate SFTSV from the Vero cells cultured with suspensions of SFTSV-infected mosquitoes [ 31 ]. Similarly, in another study, viral RNA was not detected in any tested mosquitoes, midges, and sandflies [ 11 ].…”

Section: Main Textmentioning

confidence: 99%

Vectors, Hosts, and the Possible Risk Factors Associated with Severe Fever with Thrombocytopenia Syndrome

Wang

Liu

et al. 2021

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Severe fever with thrombocytopenia syndrome (SFTS) is a disease caused by infection with the SFTS virus (SFTSV). SFTS has become a crucial public health concern because of the heavy burden, lack of vaccines, effective therapies, and high-fatality rate. Evidence suggests that SFTSV circulates between ticks and animals in nature and is transmitted to humans by tick bites. In particular, ticks have been implicated as vectors of SFTSV, where domestic or wild animals may play as the amplifying hosts. Many studies have identified antigens and antibodies against SFTSV in various animals such as sheep, goats, cattle, and rodents. Besides, person-to-person transmission through contact with blood or mucous of an infected person has also been reported. In this study, we reviewed the literature and summarized the vectors and hosts associated with SFTS and the possible risk factors.

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Experimental infections of mosquitoes with severe fever with thrombocytopenia syndrome virus

Cited by 5 publications

References 18 publications

Epidemiology of SFTS in China

Epidemiology of SFTS in China

Epidemiological Characteristics and Clinical Features of Patients With Severe Fever With Thrombocytopenia Syndrome Bunyavirus Infection

Vectors, Hosts, and the Possible Risk Factors Associated with Severe Fever with Thrombocytopenia Syndrome

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