Experimental Infection with Plasmodium Falciparum in Aotus Monkeys

Hr, Jervis; Sprinz, Helmuth; Aj, Johnson; Bt, Wellde

doi:10.4269/ajtmh.1972.21.272

Cited by 19 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several autopsy studies in adults have shown a gradation of sequestration levels among organs, with a brain 1 heart 1 lung 1 liver 1 kidney 1 skin hierarchy [17,18]. One such study was able to distinguish between complicated and uncomplicated adult malaria on the basis of the level of sequestration in these noncerebral tissues [17].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Distribution and Intensity of Parasite Sequestration in Comatose Malawian Children

Seydel

Milner

Kamiza³

et al. 2006

J INFECT DIS

123

108

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…One such study was able to distinguish between complicated and uncomplicated adult malaria on the basis of the level of sequestration in these noncerebral tissues [17]. A second was unable to find significant differences in tissue parasite densities between complicated and uncomplicated malaria [18].…”

Section: Discussionmentioning

confidence: 99%

The Distribution and Intensity of Parasite Sequestration in Comatose Malawian Children

Seydel

Milner

Kamiza³

et al. 2006

J INFECT DIS

123

108

View full text Add to dashboard Cite

show abstract

“…However, different species of the Plasmodium have also been identified in other animals (Jervis et al, 1968). The parasite capable of infecting mice is P. berghei (Anigbogu et al, 1997) and produces a disease thought to be a close replica of malaria infection in man (Dosowitz et al, 1976;Franz et al, 1987).…”

Section: Introductionmentioning

confidence: 99%

Antagonistic effect of Vitamin E on the efficacy of artesunate against Plasmodium berghei infection in mice

Awodele¹,

Emeka²,

Akintonwa³

et al. 2009

African Journal of Biomedical Research

View full text Add to dashboard Cite

The effect of antioxidant (Vitamin E) on the efficacy of Artesunate was investigated using Plasmodium berghei infected mice. Fifty (50) adult albino mice weighing between 15-25g were used for this study. There were five groups of ten animals each per group. Group I was the normal control group without the parasite and untreated, group II was infected with malaria parasite and 0.9% normal saline was administered, group III was infected with the parasite and treated with artesunate, group IV was infected with the parasaite and vitamin E was administered and group V was infected with the parasite and combination of artesunate and vitamin E were administered. Parasitaemia level and haematocrit (PCV) were monitored upon the administration of antimalaria drug -artesunate, vitamin E, normal saline and combination therapy of both vitamin E and artesunate. The life span of the infected mice was found to be between the 7 and the 10 day post inoculation, while the LD of the parasite was 156626.2 parasite/μl of blood. Artesunate was observed to rapidly clear the parasite with parasitaemia level of 21632.4 ± 513.3 parasite/μl on the 6 day, 11209.9 ± 363.7 parasite/μl on the 7 day, 1359.7 ± 14.3 parasite/μl on the 8 day, 7.8 ± 2.4 parasite/μl on the 9 day and zero parasitaemia on the 10 day. The effect of artesunate was significantly reduced when co-administered with vitamin E (p < 0.05) with parasitaemia 30542 ± 362.5 parasite/μl on the 6 day, 24705.2 ± 489.9 parasite/μl on the 7 day, 15485.0 ± 563.2 parasite/μl on the 8 day, 947.6± 37.8 parasite/μl on the 9 day and 8.0 ± 2.7 parasite/μl on the 10 day. The study suggests that co-administration of vitamin E with artesunate could reduce the efficacy of artesunate in malaria infection.

show abstract

“…However, because New World monkeys are susceptible to human falciparum malaria, they have served as important models for human malaria and drug testing, primarily owl monkeys (Aotus spp.) (e.g., [73][74][75]) and squirrel monkeys (Saimiri spp.) (e.g., [76][77][78], see 16 for a complete literature review).…”

Section: Human and Wild Primate Malarias In South Americamentioning

confidence: 99%

The Historical Ecology of Human and Wild Primate Malarias in the New World

Cormier

2010

Diversity

View full text Add to dashboard Cite

Abstract:The origin and subsequent proliferation of malarias capable of infecting humans in South America remain unclear, particularly with respect to the role of Neotropical monkeys in the infectious chain. The evidence to date will be reviewed for Pre-Columbian human malaria, introduction with colonization, zoonotic transfer from cebid monkeys, and anthroponotic transfer to monkeys. Cultural behaviors (primate hunting and pet-keeping) and ecological changes favorable to proliferation of mosquito vectors are also addressed.

show abstract

Experimental Infection with Plasmodium Falciparum in Aotus Monkeys

Cited by 19 publications

References 0 publications

The Distribution and Intensity of Parasite Sequestration in Comatose Malawian Children

The Distribution and Intensity of Parasite Sequestration in Comatose Malawian Children

Antagonistic effect of Vitamin E on the efficacy of artesunate against Plasmodium berghei infection in mice

The Historical Ecology of Human and Wild Primate Malarias in the New World

Contact Info

Product

Resources

About