Experimental infection of poults and guinea fowl with genetically distinct avian astroviruses

Novel Coronavirus and Astrovirus in Delaware Bay Shorebirds

“…Our findings indicate the importance of surveying wild bird populations for circulating viruses; the discovery of novel shorebird CoV and AstV sequences in a small sample set demonstrates the potential diversity of novel avian viruses yet to be identified. The phylogenetic relation of sanderling AstV to ANV-1 may indicate a potential for interspecies transmission between wild birds and poultry also suggested by others [21,22,23,24]. The CoV sequences reported here along with recent discoveries by others [28,29] imply a vast diversity among circulating avian CoVs and a high prevalence in wild birds [28].…”

“…The discovery of pigeon ANV that is related to chicken ANV supports the likelihood of cross-infection between pigeons and chicken [21,22]. Additional evidence for interspecies transmission among avian AstVs was provided by the identification of guinea fowl AstV, that is related to turkey AstV type 2 [23], and the subsequent experimental infections conducted with both viruses in both avian species [24]. Sanderling AstV may potentially also be capable of infecting other avian species beyond its wild bird reservoir.…”

Novel Avian Coronavirus and Fulminating Disease in Guinea Fowl, France

“…The groups reached different conclusions, proposing candidates such as toga-like virus ( 1 ), reovirus, or herpesvirus ( 2 ). More recently, astroviruses have been associated with catarrhal enteritis in guinea poults (i.e., young guinea fowl) ( 3 ), but these viruses were not detected in birds affected by fulminating disease (data not shown).…”

Pathogenesis of Chicken Astrovirus Related Illnesses

“…Since crypt epithelial cells actively divide and migrate toward the villi, it is hypothesized that CAstV would prefer immature intestinal cells. In addition, the CAstV replication cycle is documented to be short and self-limiting within a few days of infection (12,68,69). Furthermore, immunity-related studies of CAstV showed that the relative levels of gene expression of some of the important cytokines are different in the various tissue samples, which include thymus, jejunum, liver, and spleen, of the chickens infected with CAstV-WCS isolates (31).…”