EXPERIMENTAL INFECTION OF NEONATAL STRIPED SKUNKS (Mephitis mephitis) WITH INFECTIOUS BOVINE RHINOTRACHEITIS VIRUS

Lupton, H W; Jorgenson, Richard D.; Reed, David E.

doi:10.7589/0090-3558-16.1.117

Cited by 4 publications

(3 citation statements)

References 7 publications

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“…Rabbits have been infected experimentally with BHV-1 and suggested as possible laboratory models for studying the pathogenesis of BHV-1 infection (6,8,9). This study was conducted to determine whether rabbits could be persistently infected with BHV-1 and to evaluate the rabbit as a laboratory model for studying persistent BHV-1 infection.…”

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confidence: 99%

Persistent infection with bovine herpesvirus type 1: rabbit model

Rock¹,

Reed²

1982

Infect Immun

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Persistent infection with bovine herpesvirus type 1 (BHV-1) was established in all rabbits after conjunctival inoculation of virus. Spontaneous reactivations of BHV-1 with and without the appearance of recurrent ocular lesions were observed in persistently infected rabbits. BHV-1 was reactivated predictably and shed from all persistently infected rabbits after the administration of dexamethasone. During all reactivations, BHV-1 isolation was restricted to the inoculated eye.

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mentioning

confidence: 99%

Persistent infection with bovine herpesvirus type 1: rabbit model

Rock¹,

Reed²

1982

Infect Immun

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“…Thus, the inoculation of rabbits by means of the eye has become the main alternative to investigating BHV-1 in its natural host [15,20,21,38].…”

Section: Introductionmentioning

confidence: 99%

Experimental reactivation of bovine herpesvirus 1 (BHV-1) by means of corticosteroids in an intranasal rabbit model

Brown

Field

1990

Archives of Virology

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Intranasal inoculation of the rabbit was shown to be a viable alternative to eye inoculation as a model to study latency and reactivation of bovine herpesvirus 1 (BHV-1). In four different experiments, separate groups of rabbits were intranasally inoculated with BHV-1. In two experiments some rabbits were inoculated instead with a TK-defective (TK-) mutant strain of BHV-1. The development of a specific antibody response was monitored by both virus neutralization and ELISA assays. Cell-mediated immunity was measured by means of a skin test. Many weeks after virus inoculation the rabbits were treated with corticosteroid. Antibody formation after treatment was markedly different in wild type and in TK- virus inoculated groups. In the former, virus reactivation was suggested by a sudden rise in serum antibody levels with kinetics closely resembling those reported in infected calves following corticosteroid administration, whereas in the case of the TK- group no significant increase in antibody activity was measured. Histopathological changes in trigeminal ganglia also indicated reactivation of virus in the wild-type virus infected animals. Further evidence for reactivation was obtained by virus isolation from nasal swabs after corticosteroid treatment.

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“…reindeer (Nettleton et al, 1988a;1988b), swine (Woods et al, 1968;Nelson et al, 1972), ferrets (Smith 1978), striped skunks (Lupton et al, 1980a), laboratory rabbits (see below), and eastern cottontail rabbits (Lupton and Reed, 1979). Mice, rats, guinea pigs and the chick embryo are refractory to BHV1 infection Armstrong et al, 1961;Barenfus et al, 1963;Persechino et al, 1965).…”

Section: Models Of Bhv1 Infectionmentioning

confidence: 99%

Generation and characterization of virus-neutralizing bovine monoclonal antibodies to bovine herpesvirus 1 glycoproteins gB, gC, and gD

Levings

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Three bovine monoclonal antibodies (MAb) which neutralized bovine herpesvirus 1 (BHV1) were generated using a unique 'self-refusion' method. Each was determined to be directed to one of the three major neutralization targets of BHV1 (gB, gC, and gD), and was capable of passive immunization in a laboratory rabbit intravenous challenge model. They were found to be specific for the immunizing BHV1 or for BHV1 and the closely related BHV5. The epitope specificities of two were identified using characterized murine MAb. The previously unidentified combination of epitope and virus reactivity of the two bovine MAb suggest a sequence-structural difference in gB between BHV1.1 and BHV5, and an epitope adjacent to a known epitope for the anti-gD bovine MAb. Anti-idiotypic antibodies were generated against one of the bovine MAb for possible use in vaccination. Bovine MAb may offer unique advantages for research and application in diagnostics, vaccine development, and in better understanding the bovine immune response to infectious disease. CHAPTER 2. IMMUNOLOGY OF BOVINE HERPESVIRUS 1 INFECTION

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EXPERIMENTAL INFECTION OF NEONATAL STRIPED SKUNKS (Mephitis mephitis) WITH INFECTIOUS BOVINE RHINOTRACHEITIS VIRUS

Abstract: Abstract:

Cited by 4 publications

References 7 publications

Persistent infection with bovine herpesvirus type 1: rabbit model

Persistent infection with bovine herpesvirus type 1: rabbit model

Experimental reactivation of bovine herpesvirus 1 (BHV-1) by means of corticosteroids in an intranasal rabbit model

Generation and characterization of virus-neutralizing bovine monoclonal antibodies to bovine herpesvirus 1 glycoproteins gB, gC, and gD

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