Experimental Infection Models of Tuberculosis in Domestic Livestock

Buddle, Bryce M.; Vordermeier, H. Martin; Hewinson, R. Glyn

doi:10.1128/microbiolspec.tbtb2-0017-2016

Cited by 18 publications

(11 citation statements)

References 117 publications

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“…This in turn can generate confidence in the interpretation of results from experimental vaccine—challenge studies. In many domestic species, e.g., cattle, goats, and deer, the presentation of tuberculosis is similar to that observed in the greater majority of infected humans in that it is a chronic, slowly progressive disease with pathology predominantly confined to the lower respiratory tract, with associated cellular immune responses ( 73 , 74 ). However, the occurrence and prevalence of latency in these species has not been clearly established and is difficult to identify in either natural-infected or experimentally infected animals.…”

Section: Experimental Infection Models For Domestic Species and Wild mentioning

confidence: 89%

Pathogenesis of Mycobacterium bovis Infection: the Badger Model As a Paradigm for Understanding Tuberculosis in Animals

Gormley

Corner

2018

Front. Vet. Sci.

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Tuberculosis in animals is caused principally by infection with Mycobacterium bovis and the potential for transmission of infection to humans is often the fundamental driver for surveillance of disease in livestock and wild animals. However, with such a vast array of species susceptible to infection, it is often extremely difficult to gain a detailed understanding of the pathogenesis of infection--a key component of the epidemiology in all affected species. This is important because the development of disease control strategies in animals is determined chiefly by an understanding of the epidemiology of the disease. The most revealing data from which to formulate theories on pathogenesis are that observed in susceptible hosts infected by natural transmission. These data are gathered from detailed studies of the distribution of gross and histological lesions, and the presence and distribution of infection as determined by highly sensitive bacteriology procedures. The information can also be used to establish the baseline for evaluating experimental model systems. The European badger (Meles meles) is one of a very small number of wild animal hosts where detailed knowledge of the pathogenesis of M. bovis infection has been generated from observations in natural-infected animals. By drawing parallels from other animal species, an experimental badger infection model has also been established where infection of the lower respiratory tract mimics infection and the disease observed in natural-infected badgers. This has facilitated the development of diagnostic tests and testing of vaccines that have the potential to control the disease in badgers. In this review, we highlight the fundamental principles of how detailed knowledge of pathogenesis can be used to evaluate specific intervention strategies, and how the badger model may be a paradigm for understanding pathogenesis of tuberculosis in any affected wild animal species.

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Section: Experimental Infection Models For Domestic Species and Wild mentioning

confidence: 89%

Pathogenesis of Mycobacterium bovis Infection: the Badger Model As a Paradigm for Understanding Tuberculosis in Animals

Gormley

Corner

2018

Front. Vet. Sci.

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“…Most domestic mammalian species are susceptible to experimental infection. The most developed experimental models of infection of livestock are: cattle (Dean et al., ; Buddle et al., ), camelids (Stevens et al., ), pigs (Bolin et al., ), goats (de Val Pérez et al., ; Gonzalez‐Juarrero et al., ), and deer (Palmer et al., ).…”

Section: Assessmentmentioning

confidence: 99%

Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): bovine tuberculosis

More¹,

Bøtner²,

Butterworth³

et al. 2017

EFS2

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Bovine tuberculosis has been assessed according to the criteria of the Animal Health Law (AHL), in particular criteria of Article 7 on disease profile and impacts, Article 5 on the eligibility of bovine tuberculosis to be listed, Article 9 for the categorisation of bovine tuberculosis according to disease prevention and control rules as in Annex IV and Article 8 on the list of animal species related to bovine tuberculosis. The assessment has been performed following a methodology composed of information collection and compilation, expert judgement on each criterion at individual and, if no consensus was reached before, also at collective level. The output is composed of the categorical answer, and for the questions where no consensus was reached, the different supporting views are reported. Details on the methodology used for this assessment are explained in a separate opinion. According to the assessment performed, bovine tuberculosis can be considered eligible to be listed for Union intervention as laid down in Article 5(3) of the AHL. The disease would comply with the criteria as in Sections 2, 3, 4 and 5 of Annex IV of the AHL, for the application of the disease prevention and control rules referred to in points (b), (c), (d) and (e) of Article 9(1). The main animal species to be listed for bovine tuberculosis according to Article 8(3) criteria are several mammal species, as indicated in the present opinion.

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“…Previous studies have shown that the pathogenesis of bTB disease is similar to TB disease in humans and many of the features of M. tuberculosis infection are also characteristic of M. bovis infection in cattle (Buddle et al, 2016; Waters et al, 2014; Williams and Orme, 2016). Transmission is via inhalation of contaminated aerosol droplets and the primary site of infection is the lungs where the bacilli are phagocytosed by alveolar macrophages, which normally can contain or destroy intracellular bacilli (Kaufmann and Dorhoi, 2016; Weiss and Schaible, 2015).…”

Section: Introductionmentioning

confidence: 96%

Alveolar macrophage chromatin is modified to orchestrate host response toMycobacterium bovisinfection

Hall

Vernimmen

Browne

et al. 2019

Preprint

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BackgroundBovine tuberculosis is caused by infection withMycobacterium bovis, which can also cause disease in a range of other mammals, including humans. Alveolar macrophages are the key immune effector cells that first encounterM. bovisand how the macrophage epigenome responds to mycobacterial pathogens is currently not well understood.ResultsHere, we have used chromatin immunoprecipitation sequencing (ChIP-seq), RNA-seq and miRNA-seq to examine the effect ofM. bovisinfection on the bovine alveolar macrophage (bAM) epigenome. We show that H3K4me3 is more prevalent, at a genome-wide level, in chromatin fromM. bovis-infected bAM compared to control non-infected bAM; this was particularly evident at the transcriptional start sites of genes that determine programmed macrophage responses to mycobacterial infection (e.g. M1/M2 macrophage polarisation). This pattern was also supported by the distribution of RNA Polymerase II (PolII) ChIP-seq results, which highlighted significantly increased transcriptional activity at genes demarcated by permissive chromatin. Identification of these genes enabled integration of high-density GWAS data, which revealed genomic regions associated with resilience to infection withM. bovisin cattle.ConclusionsThrough integration of these data, we show that bAM transcriptional reprogramming occurs through differential distribution of H3K4me3 and PolII at key immune genes. Furthermore, this subset of genes can be used to prioritise genomic variants from a relevant GWAS data set.

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Experimental Infection Models of Tuberculosis in Domestic Livestock

Cited by 18 publications

References 117 publications

Pathogenesis of Mycobacterium bovis Infection: the Badger Model As a Paradigm for Understanding Tuberculosis in Animals

Pathogenesis of Mycobacterium bovis Infection: the Badger Model As a Paradigm for Understanding Tuberculosis in Animals

Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): bovine tuberculosis

Alveolar macrophage chromatin is modified to orchestrate host response toMycobacterium bovisinfection

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