EXPERIMENTAL INFECTION IN THE RABBIT WITH
            <i>TRICHOSPORON CAPITATUM</i>

Gilbert, Walter R.; Fetter, Bernard F.

doi:10.1128/jb.84.5.961-966.1962

Cited by 20 publications

(4 citation statements)

References 2 publications

(2 reference statements)

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“…Occasionally, abscess formation was found, always in the renal medulla. This contrasts with the finding that abscesses occurred mainly in the renal cortex of rabbits infected with T. capitatum (2). It should be noted that we could recover organisms from the spleens, livers, and lungs even though lesions could not be demonstrated in the mice.…”

Section: Discussioncontrasting

confidence: 90%

Pathogenicity and Neurological Effects of Oidiodendron kalrai for Mice

Tewari

Macpherson

1968

J Bacteriol

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An experimental infection was induced in mice by intravenous and intraperitoneal inoculation with Oidiodendron kalrai. The infected mice developed a complex neurological syndrome consisting of hyperirritability, jumping, circling, and ataxia, followed by coma and death or by apparent recovery. Visible lesions accompanied by inflammatory reaction and fungal elements were seen only in kidneys, but organisms were also identified in and isolated from the liver, spleen, lungs, and brain. Cortisone alone or in combination with streptomycin rendered the mice highly susceptible to infection with 0. kalrai, and lesions were found in the brains as well as in the kidneys of these mice. Treatment of infected mice with streptomycin alone increased the severity and duration of the neurological syndrome, but such treatment did not increase the mortality rate.

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Section: Discussioncontrasting

confidence: 90%

Pathogenicity and Neurological Effects of Oidiodendron kalrai for Mice

Tewari

Macpherson

1968

J Bacteriol

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“…Experimental models were obtained initially in rabbits and later in other animals, including irradiated mice, in which heart and kidney abscesses appeared relatively easily after intravenous infusion [6,16,17].…”

Section: Epidemiologymentioning

confidence: 99%

Invasive infections caused by Blastoschizomyces capitatus and Scedosporium spp.

Bouza

Muñóz

2004

Clinical Microbiology and Infection

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Blastoschizomyces capitatus, Scedosporium prolificans and S. apiospermum are emerging fungal pathogens that may cause disseminated disease in neutropenic patients. They can present as fever resistant to antibiotics and to wide-spectrum antifungal agents, although they may involve almost every organ. The proportion of recovery from blood cultures is high and they are characteristically resistant to most antifungal agents. Prognosis is poor unless patients recover from neutropenia. Voriconazole has good in-vitro activity and is currently the drug of choice for these infections.

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“…Although the pathogenicity of. this fungus has been documented in animai models [12] and suggested in humans [13][14] since the early 1960s, only a few cases of invasive or disseminateci infection have been reported until recently [15][16][17][18][19][20][21][22].…”

mentioning

confidence: 99%

Blastoschizomyces capitatus: An Emerging Cause of Invasive Fungal Disease in Leukemia Patients

Martino

Venditti²,

Micozzi³

et al. 1990

Clinical Infectious Diseases

125

109

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Blastoschizomyces capitatus (formerly named Trichosporon capitatum or Geotrichum capitatum) is a rare cause of invasive fungal disease in immunocompromised hosts. We retrospectively studied epidemiologie, clinical, pathologic, and microbiologie features of this infection during a 68-month period at the Division of Hematology of the University La Sapienza in Rome. Twenty patients with evidence of B. capitatus were identified: 12 were infected, four were possibly infected, and four had evidence of B. capitatus colonization but were not infected by this fungus. Pulmonary infiltrates were seen in seven infected patients; four of these patients eventualfy developed mycetomalike cavitations. Eight infected patients presented clinical and radiologie features of focal hepatitis compatible with hepatosplenic candidiasis. Of the 12 infected patients, two did not receive any antifungal treatment and died, five did not show any response to systemic antifungal therapy, and five received prolonged amphotericin B plus 5-fluorocytosine therapy. Of the last group, three patients achieved stable remission of their acute leukemia and were cured, and two improved but had an apparent relapse of B. capitatus infection after their acute leukemia recurred.

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EXPERIMENTAL INFECTION IN THE RABBIT WITH TRICHOSPORON CAPITATUM

Cited by 20 publications

References 2 publications

Pathogenicity and Neurological Effects of Oidiodendron kalrai for Mice

Pathogenicity and Neurological Effects of Oidiodendron kalrai for Mice

Invasive infections caused by Blastoschizomyces capitatus and Scedosporium spp.

Blastoschizomyces capitatus: An Emerging Cause of Invasive Fungal Disease in Leukemia Patients

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