Experimental Induction of Immediate-Type Sensitization

Abstract

Some antigens show certain sensitization specificities toward tissue. Experience has demonstrated that pollen allergy is manifested mainly by respiratory signs (c.g., rhinitis, asthma). Undoubtediy the use of adjuvants almost always produces sensitization, when M. tuberculosis is used. It is difficult to establish if these findings in adjuvants are causal. If by means of this method, easily carried out in the laboratory, a delayed type of sensitization (with or without clinical findings) is acconiplishcd with antibody response, and if we know that in man 3.1. tuberculosis produces both immediate and delayed phenomena, we can reasonably assume ail immediate sensitization mechanism in man. In othclr words, an inflammatory reaction arises with certain charac-*