Experimental immunology Oral administration of Aloe vera gel, anti-microbial and anti-inflammatory herbal remedy, stimulates cell-mediated immunity and antibody production in a mouse model

Bałan, Barbara J.; Niemcewicz, Marcin; Kocik, Janusz; Jung, Leszek; Skopińska-Różewska, Ewa; Skopiński, Piotr

doi:10.5114/ceji.2014.43711

Cited by 30 publications

(20 citation statements)

References 29 publications

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“…The results show the evidence of stimulatory activity of the above-mentioned remedies in mice [ 112 ]. Similar effects were also seen after oral administration of Aloe vera gel in mice model [ 113 ]. We also examined in vivo effect of three commercially available preparations of aforementioned plants on the neovascular reaction observed after intradermal injection of syngeneic sarcoma or xenogeneic (human) lung and kidney cancer cells [ 114 ].…”

Section: Introductionsupporting

confidence: 63%

Review paper Angiomodulatory properties of Rhodiola spp. and other natural antioxidants

Radomska-Leśniewska¹,

Skopiński²,

Bałan³

et al. 2015

cejoi

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Disturbances of angiogenesis and oxidative stress can lead to many serious diseases such as cancer, diabetes or ischemic heart disease. Substances neutralizing oxidative stress are known as antioxidants. They can affect angiogenesis process also, and thus, they modulate therapy results. Antioxidants become more and more frequently used in order to maintain homeostasis of the organism and diminish the risk of disease. Herein, we introduce some antioxidant preparations of natural plant origin (Rhodiola, Aloe vera, Resveratrol, Echinacea, Plumbagin) and antioxidant supplements (Padma 28, Reumaherb, Resvega). Analyses of their angiogenic properties, their multidirectional molecular effect on angiogenesis as well as medical application are within the scope of this review. Most of presented preparations down regulate neovascularization. They can be safely administered to patients with abnormally high angiogenesis. Rhodiola modulates, and Echinacea, Aloe vera and Plumbagin inhibit tumour-related angiogenesis in vitro and in vivo (animal models). Resveratrol and Resvega reduce neovascularization in the eye and may be applicable in eye disorders. Padma 28 preparation exhibits angioregulatory activity, decreasing high angiogenesis of cancer cells and increasing physiological angiogenesis, therefore can be used in therapy of patients with various disturbances of angiogenesis. Antioxidant application in the case of angiogenesis-related diseases should take into consideration angiogenic status of the patient.

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Section: Introductionsupporting

confidence: 63%

Review paper Angiomodulatory properties of Rhodiola spp. and other natural antioxidants

Radomska-Leśniewska¹,

Skopiński²,

Bałan³

et al. 2015

cejoi

Self Cite

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“…Aloe vera leaf extracts contain several active components such as proteins, minerals, carbohydrates, and vitamins. Aloe vera demonstrates several beneficial properties including antioxidant (Imaga et al, 2014 ), antibacterial (Ali et al, 2014 ), anti-inflammatory and as immunity regulator (Bałan et al, 2014 ). The antibacterial properties of Aloe vera gel has a great potential to be used for the treatment of skin conditions such as acne vulgaris (Hajheydari et al, 2014 ).…”

Section: Aloe Veramentioning

confidence: 99%

Natural Antioxidants: Multiple Mechanisms to Protect Skin From Solar Radiation

et al. 2018

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Human skin exposed to solar ultraviolet radiation (UVR) results in a dramatic increase in the production of reactive oxygen species (ROS). The sudden increase in ROS shifts the natural balance toward a pro-oxidative state, resulting in oxidative stress. The detrimental effects of oxidative stress occur through multiple mechanisms that involve alterations to proteins and lipids, induction of inflammation, immunosuppression, DNA damage, and activation of signaling pathways that affect gene transcription, cell cycle, proliferation, and apoptosis. All of these alterations promote carcinogenesis and therefore, regulation of ROS levels is critical to the maintenance of normal skin homeostasis. Several botanical products have been found to exhibit potent antioxidant capacity and the ability to counteract UV-induced insults to the skin. These natural products exert their beneficial effects through multiple pathways, including some known to be negatively affected by solar UVR. Aging of the skin is also accelerated by UVR exposure, in particular UVA rays that penetrate deep into the epidermis and the dermis where it causes the degradation of collagen and elastin fibers via oxidative stress and activation of matrix metalloproteinases (MMPs). Because natural compounds are capable of attenuating some of the UV-induced aging effects in the skin, increased attention has been generated in the area of cosmetic sciences. The focus of this review is to cover the most prominent phytoproducts with potential to mitigate the deleterious effects of solar UVR and suitability for use in topical application.

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“…[255][256][257][258][259] Aloe gel greatly enhances moisturizing activity and antiaging by enhancing the synthesis of collagen and elastin fibers. In addition, it also helps in the wound healing.…”

Section: Nano Aloe Veramentioning

confidence: 99%

Current application of phytocompound-based nanocosmeceuticals for beauty and skin therapy

Ganesan¹,

Choi²

2016

IJN

131

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Phytocompounds have been used in cosmeceuticals for decades and have shown potential for beauty applications, including sunscreen, moisturizing and antiaging, and skin-based therapy. The major concerns in the usage of phyto-based cosmeceuticals are lower penetration and high compound instability of various cosmetic products for sustained and enhanced compound delivery to the beauty-based skin therapy. To overcome these disadvantages, nanosized delivery technologies are currently in use for sustained and enhanced delivery of phyto-derived bioactive compounds in cosmeceutical sectors and products. Nanosizing of phytocompounds enhances the aseptic feel in various cosmeceutical products with sustained delivery and enhanced skin protecting activities. Solid lipid nanoparticles, transfersomes, ethosomes, nanostructured lipid carriers, fullerenes, and carbon nanotubes are some of the emerging nanotechnologies currently in use for their enhanced delivery of phytocompounds in skin care. Aloe vera , curcumin, resveratrol, quercetin, vitamins C and E, genistein, and green tea catechins were successfully nanosized using various delivery technologies and incorporated in various gels, lotions, and creams for skin, lip, and hair care for their sustained effects. However, certain delivery agents such as carbon nanotubes need to be studied for their roles in toxicity. This review broadly focuses on the usage of phytocompounds in various cosmeceutical products, nanodelivery technologies used in the delivery of phytocompounds to various cosmeceuticals, and various nanosized phytocompounds used in the development of novel nanocosmeceuticals to enhance skin-based therapy.

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Experimental immunology Oral administration of Aloe vera gel, anti-microbial and anti-inflammatory herbal remedy, stimulates cell-mediated immunity and antibody production in a mouse model

Cited by 30 publications

References 29 publications

Review paper Angiomodulatory properties of Rhodiola spp. and other natural antioxidants

Review paper Angiomodulatory properties of Rhodiola spp. and other natural antioxidants

Natural Antioxidants: Multiple Mechanisms to Protect Skin From Solar Radiation

Current application of phytocompound-based nanocosmeceuticals for beauty and skin therapy

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