Experimental Hypothermia: Respiratory and Blood p<scp>h</scp> Changes in Relation to Cardiac Function

Osborn, John J.

doi:10.1152/ajplegacy.1953.175.3.389

Cited by 462 publications

(200 citation statements)

References 0 publications

Supporting

Mentioning

186

Contrasting

Unclassified

Order By: Relevance

“…6,24,25 This deflection was thought to be due to myocardial anoxia, or to represent a current of injury and to herald ventricular fibrillation. 7,24 However, subsequent studies found no correlation between the time of onset or prominence of the deflection and the onset of ventricular fibrillation. 15 In a report of 47 anesthetized dogs, an increase in amplitude of the so-called ''characteristic slowly-inscribed inflection'' occurred as the temperature fell.…”

Section: Discussionmentioning

confidence: 98%

“…3 Slowing of the heart rate and slowing of the spread of excitation with lengthening of PR, QRS, and QT intervals seen on the ECG were subsequently demonstrated in multiple animal models. [4][5][6][7][8][9][10][11][12]15 One of these studies resulted in the adoption of the eponym ''Osborn'' wave for the characteristic deflection at the end of the QRS complex. 7 In 1943, the first description of the deflection at the end of the QRS was reported in dogs.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A Prospective Evaluation of the Electrocardiographic Manifestations of Hypothermia

Vassallo

Delaney

Hoffman

et al. 1999

Academic Emergency Medicine

View full text Add to dashboard Cite

Abstract. Objective: To determine the effects of body temperature, ethanol use, electrolyte status, and acid-base status on the electrocardiograms (ECGs) of hypothermic patients. Methods: Prospective, two-year, observational study of patients presenting to an urban ED with temperature Յ95ЊF (Յ35ЊC). All patients had at least one ECG obtained. Electrocardiograms were interpreted by a cardiologist blinded to the patient's temperature. J-point elevations known as Osborn waves were defined as present if they were at least 1 mm in height in two consecutive complexes. Results: 100 ECGs were obtained in 43 patients. Presenting temperatures ranged between 74ЊF and 95ЊF (23.3ЊC-35ЊC). Initial rhythms included normal sinus (n = 34), atrial fibrillation (n = 8), and junctional (n = 1). Osborn waves were present in 37 of 43 initial ECGs. Of the six initial ECGs that did not have Osborn waves present, all were obtained in patients whose temperatures were Ն90ЊF (Ն32.2ЊC). For the entire group, the Osborn wave was significantly larger as temperature decreased (p = 0.0001, r = Ϫ0.441). The correlation between temperature and size of the Osborn wave was strongest in six patients with four or more ECGs (range r = Ϫ0.644 to r = Ϫ0.956, p = 0.001). No correlation could be demonstrated between the height of the Osborn waves and the serum electrolytes, including sodium, chloride, potassium, bicarbonate, BUN, creatinine, glucose, anion gap, and blood ethanol levels. Conclusions: The presence and size of the Osborn waves in hypothermic patients appear to be a function of temperature. The magnitude of the Osborn waves is inversely correlated with the temperature. Key words: hypothermia, electrocardiograph; Osborn waves. AC-ADEMIC EMERGENCY MEDICINE 1999; 6:1121-1126 T HE EFFECTS of hypothermia on cardiac conduction were first described in 1892.1 Since then, observations of the physiologic changes that occur with cooling of the heart have been reported in animals 2-14 and in humans undergoing craniotomy for subarachnoid hemorrhage, 15 surgery for cardiac anomalies, [16][17][18][19] and anti-cancer therapy. 20,21The first observation of the changes in the electrocardiogram (ECG) in a patient with unintentional hypothermia was reported in 1938. 22 In the following study, the changes in the ECGs of patients with unintentional hypothermia presenting to a large urban hospital ED are described, and the relationship of these changes to common laboratory parameters are analyzed. A review of the literature focuses on the development of the understanding of the effects of cold on the electrical conduction system of the heart and the resultant physiologic and ECG alterations. METHODSStudy Design. This was a prospective, two-year observational study of hypothermia patients presenting to an urban ED. The study was approved by the institutional review boards of New York University School of Medicine, Bellevue Hospital, and the New York City Health and Hospital Corporation.Study Setting and Population. For the purposes of this study, patients were sele...

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

A Prospective Evaluation of the Electrocardiographic Manifestations of Hypothermia

Vassallo

Delaney

Hoffman

et al. 1999

Academic Emergency Medicine

View full text Add to dashboard Cite

show abstract

“…The J wave was first reported by Kraus in a hypercalcemic patient in 1920 and later reported by Tomaszewski in a hypothermic patient in 1938 [7,8]. In 1953, John Osborn described the Osborn waves that resulted in ventricular fibrillation on electrocardiography in an experimental hypothermia model on dogs [9].…”

Section: Discussionmentioning

confidence: 99%

“…Osborn wave is a characteristic ECG finding of hypothermia. The Osborn wave is described as a small positive deflection wave (>1mm) at the junction corresponding to the end of the QRS complex and the beginning of the ST segment in two consecutive beats [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

A case of hypothermia with significant Osborn Wave: a forgotten electrocardiographic finding

Demir¹,

Ede²,

Yılmaz³

et al. 2017

Med-Science

View full text Add to dashboard Cite

Hypothermia is generally defined as the body's internal temperature below 35 °C. Hypothermia is classified as primer and secondary hypothermia according to its mechanism, and as mild (32 to 35 °C), moderate (32-28 °C) and severe (below 28°C) hypothermia according to body temperature. The characteristic electrocardiographic finding of the hypothermia is the Osborn (j) wave, which is manifested as a small positive deflection wave (late delta wave) at the junction corresponding to the end of the QRS complex and the beginning of the ST segment in two consecutive beats. In this article, we aimed to present a case of 68-year-old man, who was found in cold weather, having lost consciousness and hypothermia, and whose electrocardiogram showed an Osborn wave which was resolved with the increase of body temperature.

show abstract

“…First-degree and third degree heart blocks develop with increasing severity of hypothermia; at <30°C and 20°C respectively. Osborn JJdescribed J wave or elevated J-point in experimental hypothermia in 1953 [6]. It is a deflection that appears Management of hypothermia should be aggressive.…”

Section: Discussionmentioning

confidence: 99%

Management of Hypothermia with Warm Peritoneal Dialysis

Muthukrishnan¹,

Dhul²,

Dhall³

et al. 2003

Medical Journal Armed Forces India

View full text Add to dashboard Cite

Experimental Hypothermia: Respiratory and Blood ph Changes in Relation to Cardiac Function

Cited by 462 publications

References 0 publications

A Prospective Evaluation of the Electrocardiographic Manifestations of Hypothermia

A Prospective Evaluation of the Electrocardiographic Manifestations of Hypothermia

A case of hypothermia with significant Osborn Wave: a forgotten electrocardiographic finding

Management of Hypothermia with Warm Peritoneal Dialysis

Contact Info

Product

Resources

About