Experimental hypertension of the rat: Reciprocal changes of norepinephrine turnover in heart and brain-stem

Nakamura, Kazuo; Gerold, M.; Thoenen, H.

doi:10.1007/bf01020067

Cited by 135 publications

(24 citation statements)

References 21 publications

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“…The report of decreased noradrenaline synthesis and content of the brain stem and hypothalamus of spontaneously hypertensive rats (Yamori, Lovenberg & Sjoerdsma, 1970) supports this concept as does the finding of decreased turnover rate of noradrenaline in the brain stem of DOCA/saline hypertensive rats (Nakamura, Gerold & Thoenen, 1971). Yamabe, de Jong & Lovenberg (1973) reported increased dopamine levels in the telencephalon of spontaneously hypertensive rats whilst Spring & Winkelmuller (1975) …”

Section: Effect Of Central Dopamine Receptor Blockadesupporting

confidence: 57%

Cardiovascular Effects of Dopamine After Central Administration Into Conscious Cats

Day

Roach

1976

British J Pharmacology

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Dopamine (30 and 45 μg) administered intracerebroventricularly (i.c.v.) to a group of 10 conscious normotensive cats caused dose‐related increases in blood pressure and heart rate. In 4 of these animals the initial cardiovascular stimulant effects of i.c.v. dopamine were followed by hypotension and bradycardia. α‐Methyldopamine (30 and 45 μg i.c.v.) produced qualitatively similar responses to dopamine except that the cardiovascular stimulant effects were smaller and the secondary depressant effects somewhat more prolonged. Both stimulant and depressant effects of i.c.v. dopamine and α‐methyldopamine were greatly inhibited by autonomic ganglion blockade or by adrenergic neurone blockade. The cardiovascular stimulant effects of both i.c.v. dopamine and i.c.v. α‐methyldopamine were selectively inhibited by β‐adrenoceptor blocking agents whilst the cardiovascular depressant effects of these substances were abolished by the α‐adrenoceptor blocker phentolamine or by the dopamine‐β‐hydroxylase inhibitor disulfiram. Haloperidol by either i.c.v. or the intravenous route abolished both cardiovascular stimulant and depressant effects of i.c.v. dopamine, whilst pimozide by either route inhibited only the cardiovascular stimulant effects. In 2 cats, injection of dopamine into the cisterna magna produced predominantly depressant effects on the cardiovascular system except with a higher dose which induced biphasic responses.

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Section: Effect Of Central Dopamine Receptor Blockadesupporting

confidence: 57%

Cardiovascular Effects of Dopamine After Central Administration Into Conscious Cats

Day

Roach

1976

British J Pharmacology

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“…Plasma norepinephrine in the rat is principally derived from neurotransmitter released from noradrenergic nerve endings and appears to correlate well with other indices of sympathetic function (19,(35)(36)(37). We therefore interpret the elevation of plasma norepinephrine observed in the one-kidney renal hypertensive rat as a consequence of enhanced neurotransmitter release secondary to increased sympathetic neuronal activity.…”

Section: Discussionmentioning

confidence: 81%

Decrease in Peripheral Sympathetic Nervous System Activity following Renal Denervation or Unclipping in the One-Kidney One-Clip Goldblatt Hypertensive Rat

Katholi¹,

Winternitz²,

Oparil³

1982

J. Clin. Invest.

104

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A B S T R A C T Increased sympathetic nervous system activity has been demonstrated in established one-kidney one-clip hypertension in the rat. We have found that renal denervation in this model results in an attenuation of hypertension, unassociated with alterations in sodium or water balance or renin activity. To determine whether the depressor effect of renal denervation is associated with changes in peripheral sympathetic nervous system activity, sham operation (n = 12), renal denervation (n = 13), or unclipping (n = 13) was carried out 2 wk after the onset of onekidney one-clip hypertension. Normotensive uninephrectomized age-and sex-matched rats were used as controls (n = 14). Renal denervation resulted in a significant decrease in systolic blood pressure (201±7 to 151±6 mm Hg), while unclipping lowered systolic blood pressure to normotensive levels (130±6 mm Hg). 8 d after operation plasma norepinephrine and mean arterial pressure before and after ganglionic blockade with 30 mg/kg hexamethonium bromide were measured in conscious, unrestrained, resting animals, as indices of peripheral sympathetic nervous system activity. Plasma norepinephrine was significantly higher in hypertensive sham-operated rats (422±42 pg/ml) compared with normotensive controls (282±25 pg/ml) (P < 0.01). Both renal denervation and unclipping restored plasma norepinephrine to normal levels (273±22 and 294±24 pg/ml, respectively). Ganglionic blockade in hypertensive sham-operated animals resulted in a significantly greater decrease in mean arterial pressure than occurred in renal denervated, unclipped, or control rats. The data suggest that the depressor effect of renal denervation or unclipping in the one-kidney oneAddress reprints requests to Dr. R. E. Katholi.

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“…These tissues from 3 rats were pooled for DOPAC determinations. Cerebral regions were dissected as described previously (16,17).…”

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confidence: 99%

Behavioral and Neurochemical Changes Following Administration of 6-Hydroxydopamine Into the Ventral Tegmental Area of the Midbrain

Nakamura

1976

Japanese Journal of Pharmacology

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Experimental hypertension of the rat: Reciprocal changes of norepinephrine turnover in heart and brain-stem

Cited by 135 publications

References 21 publications

Cardiovascular Effects of Dopamine After Central Administration Into Conscious Cats

Cardiovascular Effects of Dopamine After Central Administration Into Conscious Cats

Decrease in Peripheral Sympathetic Nervous System Activity following Renal Denervation or Unclipping in the One-Kidney One-Clip Goldblatt Hypertensive Rat

Behavioral and Neurochemical Changes Following Administration of 6-Hydroxydopamine Into the Ventral Tegmental Area of the Midbrain

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