Natural fractures in reservoirs can be the cause of many adverse effects during hydraulic fracturing treatment. In the present paper, hydraulic fracturing tests are used to investigate the interaction of a propagating hydraulic fracture with a natural fracture in the fractured blocks. Systematic experiments were designed and performed on the cement blocks with different pre-existing fracture strikes and dips (30°, 60°and 90°). The effect of horizontal stress difference on the propagation of hydraulic fractures was also determined through a series of experiments with different values for Dr, which were 5 and 10 MPa, respectively. Propagation arrest of the hydraulic fracture and crossing the pre-existing fracture were two dominating fracture behaviors at horizontal stress differences of 5 and 10 MPa, respectively. It was observed that both the magnitude of differential stress and the preexisting fracture geometry can magnify the effect of a preexisting fracture on hydraulic fracture propagation. When the horizontal differential stress is low (5 MPa), the hydraulic fracture crosses the pre-existing fracture at a high pre-existing fracture dip (90°) and at an intermediate to high pre-existing fracture strike (60°-90°), while hydraulic fracture is arrested by the opening of the pre-existing fracture at a pre-existing fracture strike (30°). Meanwhile, when the pre-existing fracture dip is low to intermediate (30°-60°) and its strike is low to high (30°-90°), hydraulic fracture is arrested by the opening and shear slippage of the pre-existing fracture in this situation. However, at a high horizontal differential stress (10 MPa), when the preexisting fracture dip is low to high (30°-90°), the hydraulic fracture crosses the pre-existing fracture at the strike of the pre-existing fracture of 60°-90°, and when it is decreased to 30°, the hydraulic fracture is arrested by th eopening and shear slippage of the pre-existing fracture. Therefore, the pre-existing fracture's strike and dip play a significant role in the propagation of hydraulic fracture at a low horizontal stress difference, while the role of the pre-existing fracture dip at a high horizontal stress difference is less than the pre-existing fracture strike on the propagation of hydraulic fracture. Keywords Hydraulic fracture propagation Á Laboratory experiments Á The pre-existing fracture strike and dip Á Horizontal stress difference List of symbols l Fluid viscosity, m/Lt (Pa s) r h Minimum principal stress in horizontal direction, m/Lt 2 (Pa) r H Maximum principal stress in horizontal direction, m/Lt 2 (Pa) r v Principal stress in vertical direction, m/Lt 2 (Pa) D r Horizontal stress difference, m/Lt 2 (Pa) p Fluid pressure, m/Lt 2 (psi) q Flow rate of fluid, L 3 /t (m 3 /s) E Young's modulus of elasticity, m/Lt 2 (Pa) m Poisson's ratio r c Unconfined compressive strength, m/Lt 2 (Pa)