Experimental examination of radiation doses from cardiac and liver CT perfusion in a phantom study as a function of organ, age and sex

Bos, Denise; König, Britta; Blex, Sebastian; Zensen, Sebastian; Opitz, Marcel; Maier, Sandra; Forsting, Michael; Zylka, Waldemar; Kühl, Hilmar; Wetter, Axel; Guberina, Nika

doi:10.1088/1361-6498/abf71f

Cited by 2 publications

(1 citation statement)

References 37 publications

(52 reference statements)

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“…In total, 3 pulmonary nodules are subsolid, and 6 pulmonary nodules are solid. Of note, spherical nodules without spiculae were used in the present phantom study, as described earlier [ 19 , 20 ]. The phantom was scanned in a supine and arms-abducted position, taken head first into the CT scanner, with a dedicated chest CT protocol.…”

Section: Methodsmentioning

confidence: 99%

Experimental Examination of Conventional, Semi-Automatic, and Automatic Volumetry Tools for Segmentation of Pulmonary Nodules in a Phantom Study

Hlouschek,

König,

Bos

et al. 2023

Diagnostics

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The aim of this study is to examine the precision of semi-automatic, conventional and automatic volumetry tools for pulmonary nodules in chest CT with phantom N1 LUNGMAN. The phantom is a life-size anatomical chest model with pulmonary nodules representing solid and subsolid metastases. Gross tumor volumes (GTVis) were contoured using various approaches: manually (0); as a means of semi-automated, conventional contouring with (I) adaptive-brush function; (II) flood-fill function; and (III) image-thresholding function. Furthermore, a deep-learning algorithm for automatic contouring was applied (IV). An intermodality comparison of the above-mentioned strategies for contouring GTVis was performed. For the mean GTVref (standard deviation (SD)), the interquartile range (IQR)) was 0.68 mL (0.33; 0.34–1.1). GTV segmentation was distributed as follows: (I) 0.61 mL (0.27; 0.36–0.92); (II) 0.41 mL (0.28; 0.23–0.63); (III) 0.65 mL (0.35; 0.32–0.90); and (IV) 0.61 mL (0.29; 0.33–0.95). GTVref was found to be significantly correlated with GTVis (I) p < 0.001, r = 0.989 (III) p = 0.001, r = 0.916, and (IV) p < 0.001, r = 0.986, but not with (II) p = 0.091, r = 0.595. The Sørensen–Dice indices for the semi-automatic tools were 0.74 (I), 0.57 (II) and 0.71 (III). For the semi-automatic, conventional segmentation tools evaluated, the adaptive-brush function (I) performed closest to the reference standard (0). The automatic deep learning tool (IV) showed high performance for auto-segmentation and was close to the reference standard. For high precision radiation therapy, visual control, and, where necessary, manual correction, are mandatory for all evaluated tools.

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Section: Methodsmentioning

confidence: 99%

Experimental Examination of Conventional, Semi-Automatic, and Automatic Volumetry Tools for Segmentation of Pulmonary Nodules in a Phantom Study

Hlouschek,

König,

Bos

et al. 2023

Diagnostics

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Basis and current state of computed tomography perfusion imaging: a review

Zeng¹,

Zeng²,

Sui³

et al. 2022

Phys. Med. Biol.

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Computed tomography perfusion (CTP) is a functional imaging that allows for providing capillary-level hemodynamics information of the desired tissue in clinics. In this paper, we aim to offer insight into CTP imaging which covers the basics and current state of CTP imaging, then summarize the technical applications in the CTP imaging as well as the future technological potential. At first, we focus on the fundamentals of CTP imaging including systematically summarized CTP image acquisition and hemodynamic parameter map estimation techniques. A short assessment is presented to outline the clinical applications with CTP imaging, and then a review of radiation dose effect of the CTP imaging on the different applications is presented. We present a categorized methodology review on known and potential solvable challenges of radiation dose reduction in CTP imaging. To evaluate the quality of CTP images, we list various standardized performance metrics. Moreover, we present a review on the determination of infarct and penumbra. Finally, we reveal the popularity and future trend of CTP imaging.

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Experimental examination of radiation doses from cardiac and liver CT perfusion in a phantom study as a function of organ, age and sex

Cited by 2 publications

References 37 publications

Experimental Examination of Conventional, Semi-Automatic, and Automatic Volumetry Tools for Segmentation of Pulmonary Nodules in a Phantom Study

Experimental Examination of Conventional, Semi-Automatic, and Automatic Volumetry Tools for Segmentation of Pulmonary Nodules in a Phantom Study

Basis and current state of computed tomography perfusion imaging: a review

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