Experimental examination of anti-inflammatory effects of a 5-HT3 receptor antagonist, tropisetron, and concomitant effects on autonomic nervous function in a rat sepsis model

Setoguchi, Daisuke; Nakamura, Masataka; Yatsuki, Henry; Watanabe, Eizo; Tateishi, Yohei; Kuwaki, Tomoyuki; Oda, Shigeto

doi:10.1016/j.intimp.2011.08.022

Cited by 22 publications

(12 citation statements)

References 41 publications

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“…Previous animal experiments have demonstrated that the LPS can induce inflammatory response syndrome, leading to severe pro-inflammatory reaction with subsequent acute hypotension, multi-organ failure (MOF), and even death (Davies & Cohen, 2011;Huttunen & Aittoniemi, 2011). Additionally, it is reported that neutralization or removal LPS would be a successful approach for the treatment of sepsis (Cruz et al, 2009;Davies & Cohen, 2011;Setoguchi et al, 2011). In our present study, our results demonstrated that the serum LPS can be significantly neutralized by treating with AT-I in a dose-dependent manner, which indicated that AT-I might have therapeutic effect on sepsis.…”

Section: Discussionmentioning

confidence: 99%

The protective effect of atractylenolide I on systemic inflammation in the mouse model of sepsis created by cecal ligation and puncture

Wang

Xiao

Zhou

et al. 2015

Pharmaceutical Biology

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Objective: Our present study is designed to investigate the protective effect of AT-I on systemic inflammation in the mouse model of sepsis created by cecal ligation and puncture (CLP), and explore the possible mechanism. Materials and methods: Sepsis mouse model was established by CLP, and the tested dosages of AT-I were 10, 20, and 40 mg/kg (ip). Pro-inflammatory cytokines in serum (TNF-a, IL-1b and IL-6) were determined by the ELISA method; serum lipopolysaccharide (LPS) level was measured by the Limulus Amebocyte Lysate (LAL) test; white blood cells (WBC) were counted by Blood cell analyzer; contents of alanine transaminase (ALT), aspartate transarninase (AST), creatinine (Cre), and blood urea nitrogen (BUN) in serum were determined by automatic biochemistry analyzer. For survival rate tests, CLP mice were observed within 7 days, and body temperature was measured at 0, 4, 8, 12, 24, 48 and 72 h after surgery. Results: Our results indicated that AT-I significantly increased the survival rate of mice with sepsis (p50.05), whereas the WBCs and levels of LPS, pro-inflammatory cytokines (TNF-a, IL-1b and IL-6), ALT, AST, Cre, and BUN decreased significantly after treatment with AT-I (p50.05). Conclusion:In conclusion, the AT-I ameliorates sepsis syndrome by reduction of proinflammatory cytokines and LPS, and provides an improvement in liver and kidney functions.

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Section: Discussionmentioning

confidence: 99%

The protective effect of atractylenolide I on systemic inflammation in the mouse model of sepsis created by cecal ligation and puncture

Wang

Xiao

Zhou

et al. 2015

Pharmaceutical Biology

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“…Cecal ligation and puncture (CLP) model of rats was prepared as the method described previously (Rittirsch et al, 2009;Setoguchi et al, 2011). In brief, rats were general anesthetized with isoflurane (3 mL/kg), and an abdominal midline incision (approximately 3 cm long) was made after disinfection of the abdomen.…”

Section: Preparation Of Cecal Ligation and Puncture Model Of Ratsmentioning

confidence: 99%

Protective effect of curcumin against cardiac dysfunction in sepsis rats

Yang¹,

Wu²,

Shanghai³

et al. 2013

Pharmaceutical Biology

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“…In particular, tropisetron was demonstrated to be consistently effective as a corticosteroid therapy for rheumatoid diseases in humans. 35) Therefore, serotonin/5-HT 3 receptor pathways offer new knowledge on the regulation of immune and inflammatory responses, and the 5-HT 3 receptor antagonists may be a new class of antiinflammatory drugs. In addition, 5-HT 3 receptor antagonists may be considered a relatively safe treatment for inflammatory diseases of the GI tract, compared with NSAIDs and corticosteroids.…”

Section: Resultsmentioning

confidence: 99%

Role of Serotonin 5-HT<sub>3</sub> Receptors in Intestinal Inflammation

Kato

2013

Biological & Pharmaceutical Bulletin

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Serotonin (5-hydroxytryptamine; 5-HT), a well-characterized neurotransmitter in the central nervous system, plays a crucial role in regulating mood, body temperature, sleep, appetite, and metabolism. Serotonin is synthesized in the serotonergic neuron of the central nervous system; however, approximately 90% of serotonin is synthesized and localized in the gastrointestinal (GI) tract, especially in the enterochromaffin (EC) cells. In the GI tract, serotonin mediates control over a variety of physiological functions such as contraction/relaxation of smooth muscle, and peristaltic and secretory reflexes, directly or indirectly through intrinsic primary afferent neurons. The receptors mediating the action of serotonin are mainly classified into 7 major groups known as the 5-HT1 to 5-HT7 receptors. The 5-HT3 receptor is distinguished from among the other 5-HT receptor subtypes because it is only a ligand-gated ion channel, whereas the other subtypes serve as G protein-coupled receptors. The 5-HT3 receptor, which is generally considered to be localized in the central and peripheral nervous systems, is involved in processes associated with emotion, cognition, memory, pain perception, and GI functions including secretion and motility. Recently, an increasing number of findings have provided evidence of the important role of the 5-HT3 receptor in the regulation of inflammatory and immune responses. In fact, several 5-HT3 receptor antagonists have been reported to ameliorate intestinal inflammation. Therefore, this review focuses on the role of 5-HT3 receptors in the pathogenesis of intestinal inflammation.

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Experimental examination of anti-inflammatory effects of a 5-HT3 receptor antagonist, tropisetron, and concomitant effects on autonomic nervous function in a rat sepsis model

Cited by 22 publications

References 41 publications

The protective effect of atractylenolide I on systemic inflammation in the mouse model of sepsis created by cecal ligation and puncture

The protective effect of atractylenolide I on systemic inflammation in the mouse model of sepsis created by cecal ligation and puncture

Protective effect of curcumin against cardiac dysfunction in sepsis rats

Role of Serotonin 5-HT<sub>3</sub> Receptors in Intestinal Inflammation

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