Experimental evolution for the recovery of growth loss due to genome reduction
Kenya Hitomi,
Yoichiro Ishii,
Bei-Wen Ying
Abstract:As the genome encodes the information crucial for cell growth, a sizeable genomic deficiency often causes a significant decrease in growth fitness. Whether and how the decreased growth fitness caused by genome reduction could be compensated by evolution was investigated here. Experimental evolution with an
Escherichia coli
strain carrying a reduced genome was conducted in multiple lineages for approximately 1,000 generations. The growth rate, which was largely declined due to genome reduction, was considerab… Show more
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