Experimental evidences of 95 m Tc production in a nuclear reactor

Cohen, I. M.; Robles, Aladino; Mendoza, Pablo; Airas, R.M.; Montoya, Eduardo

doi:10.1016/j.apradiso.2018.02.001

Cited by 8 publications

(6 citation statements)

References 9 publications

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“…Technetium-99 ( t 1/2 = 2.13 × 10 5 years) can be found in uranium-containing pitchblende ore as a natural fission product of 238 U. Other long-lived Tc isotopes include 97 Tc ( t 1/2 = 4.21 × 10 6 years) and 98 Tc ( t 1/2 = 4.20 × 10 6 years), which are reactor produced . These long-lived isotopes are not of particular relevance for nuclear medicine applications except 99 Tc, which is used as a long-lived congener to study Tc chemistry on a macroscopic level.…”

Section: Technetiummentioning

confidence: 99%

“…Other long-lived Tc isotopes include 97 produced. 155 These long-lived isotopes are not of particular relevance for nuclear medicine applications except 99 Tc, which is used as a long-lived congener to study Tc chemistry on a macroscopic level. For nuclear medicine applications, 99m Tc (t 1/2 = 6 h, E γ = 141 keV (89%)) is used extensively for singlephoton imaging, and >85% of all nuclear medicine studies are carried out using 99m Tc radiopharmaceuticals.…”

Section: Technetium 111 Common Radionuclides and Their Propertiesmentioning

confidence: 99%

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Radioactive Transition Metals for Imaging and Therapy

2018

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Nuclear medicine is composed of two complementary areas, imaging and therapy. Positron emission tomography (PET) and single-photon imaging, including single-photon emission computed tomography (SPECT), comprise the imaging component of nuclear medicine. These areas are distinct in that they exploit different nuclear decay processes and also different imaging technologies. In PET, images are created from the 511 keV photons produced when the positron emitted by a radionuclide encounters an electron and is annihilated. In contrast, in single-photon imaging, images are created from the γ rays (and occasionally X-rays) directly emitted by the nucleus. Therapeutic nuclear medicine uses particulate radiation such as Auger or conversion electrons or β − or α particles. All three of these technologies are linked by the requirement that the radionuclide must be attached to a suitable vector that can deliver it to its target. It is imperative that the radionuclide remain attached to the vector before it is delivered to its target as well as after it reaches its target or else the resulting image (or therapeutic outcome) will not reflect the biological process of interest. Radiochemistry is at the core of this process, and radiometals offer radiopharmaceutical chemists a tremendous range of options with which to accomplish these goals. They also offer a wide range of options in terms of radionuclide half-lives and emission properties, providing the ability to carefully match the decay properties with the desired outcome. This Review provides an overview of some of the ways this can be accomplished as well as several historical examples of some of the limitations of earlier metalloradiopharmaceuticals and the ways that new technologies, primarily related to radionuclide production, have provided solutions to these problems.

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Section: Technetiummentioning

confidence: 99%

Section: Technetium 111 Common Radionuclides and Their Propertiesmentioning

confidence: 99%

Radioactive Transition Metals for Imaging and Therapy

2018

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“…99m Tc (t 1/2 = 6,02 h, E = 140.5 keV (89%)) is widely used for SPECT, with 99m Tc radiopharmaceuticals accounting for more than 85% of all nuclear medicine studies [ 57 ]. The emission and half time of 99m Tc are almost ideal for convenient preparation of radiopharmaceuticals and imaging applications [ 58 ].…”

Section: Radionuclidesmentioning

confidence: 99%

The Chemical Scaffold of Theranostic Radiopharmaceuticals: Radionuclide, Bifunctional Chelator, and Pharmacokinetics Modifying Linker

et al. 2022

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Therapeutic radiopharmaceuticals have been researched extensively in the last decade as a result of the growing research interest in personalized medicine to improve diagnostic accuracy and intensify intensive therapy while limiting side effects. Radiometal-based drugs are of substantial interest because of their greater versatility for clinical translation compared to non-metal radionuclides. This paper comprehensively discusses various components commonly used as chemical scaffolds to build radiopharmaceutical agents, i.e., radionuclides, pharmacokinetic-modifying linkers, and chelators, whose characteristics are explained and can be used as a guide for the researcher.

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“…Data of neutron flux distribution at CIP is of great significance for designing irradiation facilities of PTRRB. Among its application is for producing radioisotope, as demonstrated in various reactors [3][4][5][6][7]. Examples of radioisotope produced in a research reactor are Mo-99/Tc-99m, Pm-149, Tb-161, and I-131 [8][9][10][11][12].…”

Section: Introduction *mentioning

confidence: 99%

Design of Irradiation Facilities at Central Irradiation Position of Plate Type Research Reactor Bandung

Bahrum¹,

Handiaga²,

Setiadi³

et al. 2020

Tri Dasa Mega

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One of the results from Plate Type Research Reactor Bandung (PTRRB) research program is PTRRB core design. Previous study on PTRRB has not calculated neutron flux distribution at its central irradiation position (CIP). Distribution of neutron flux at CIP is of high importance especially in radioisotope production. In this study, CIP was modeled as a stack of four to five aluminum tubes (AT), each filled by four aluminum irradiation capsules (AIC). Considering AIC dimension and geometry, there are three possibilities of AT configuration. For irradiation sample, 1.45 gr of molybdenum (Mo) was put into AIC. Neutron flux distribution at Mo sample was calculated using TRIGA MCNP and MCNP software. The calculation was simulated at condition when fresh fuel is loaded into reactor core. Analyses of excess reactivity show that, after installing irradiation AT and Mo sample was put into each configuration, the excess reactivity is less than 10.9 %. The highest calculated thermal neutron flux at Mo sample is 5.08×1013 n/cm2.s at configuration 1. Meanwhile, the highest total neutron flux at Mo sample is located at capsule no. II and III. Thermal neutron flux profile is the same for all configurations. This result will be used as a basic data for PTRRB utilization.Keywords: Central Irradiation Position, Neutron Flux Distribution, MCNP, PTRRB

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Experimental evidences of 95 m Tc production in a nuclear reactor

Cited by 8 publications

References 9 publications

Radioactive Transition Metals for Imaging and Therapy

Radioactive Transition Metals for Imaging and Therapy

The Chemical Scaffold of Theranostic Radiopharmaceuticals: Radionuclide, Bifunctional Chelator, and Pharmacokinetics Modifying Linker

Design of Irradiation Facilities at Central Irradiation Position of Plate Type Research Reactor Bandung

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Experimental evidences of 95 m Tc production in a nuclear reactor

Cited by 8 publications

References 9 publications

Radioactive Transition Metals for Imaging and Therapy

Radioactive Transition Metals for Imaging and Therapy

The Chemical Scaffold of Theranostic Radiopharmaceuticals: Radionuclide, Bifunctional Chelator, and Pharmacokinetics Modifying Linker

Design of Irradiation Facilities at Central Irradiation Position of Plate Type Research Reactor Bandung

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Experimental evidences of 95 m Tc production in a nuclear reactor