2009
DOI: 10.1080/00016480802623963
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Experimental evidence suggestive of early intervention in mucoid otitis media

Abstract: The experimental ears in both groups were observed to undergo gradual pathological changes with increasing survival times. The acute inflammatory phase turned into chronic irreversible changes, which correlated directly with the initial amount of effusion and the areas of epithelial breaks, granulation tissue, cholesterol granuloma, and epithelial migration.

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Cited by 9 publications
(7 citation statements)
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“…Otitis Media with Effusion, OME) [14,15]. Niezdiagnozowany OME może prowadzić do czasowych lub stałych przewodzeniowych ubytków słuchu [16][17][18]. Określenie czynności trąbki słuchowej przed zabiegami operacyjnymi w uchu środkowym często decyduje o powodzeniu leczenia lub jego braku [19,20].…”
Section: Wstępunclassified
“…Otitis Media with Effusion, OME) [14,15]. Niezdiagnozowany OME może prowadzić do czasowych lub stałych przewodzeniowych ubytków słuchu [16][17][18]. Określenie czynności trąbki słuchowej przed zabiegami operacyjnymi w uchu środkowym często decyduje o powodzeniu leczenia lub jego braku [19,20].…”
Section: Wstępunclassified
“…By that time, irreversible damages might have taken place. Experimental studies in Chinchillas have demonstrated that the relationship between the time of evolution of effusion and structural changes of mucoperiosteum are related [4]. In this context, we should regularly follow up patients who are having OME and likely to have OME because of very frequent URTI (Figure3).…”
Section: Otitis Media With Effusion: a Silent Killer Of Middle Ear -At Least In A Few Patients Opinionmentioning
confidence: 99%
“…24 In human beings and dogs, CG and ear cholesteatoma may coexist. 21,24 Cholesterol granuloma of the middle ear has been experimentally induced in several species of animal including cats, 7,10 chinchilla (Chinchilla lanigera), 10 and squirrel monkeys (Saimiri spp.). 9 In these previous experiments, obstruction of Eustachian tube alone 9 or along with tympanic membrane perforation with or without introduction of foreign material in the middle ear 7,10 was used to successfully induce CG formation.…”
Section: Research-article2013mentioning
confidence: 99%
“…Cholesterol granuloma formation was experimentally induced in the tympanic bullae of cats, 7,10 and has been experimentally induced in cats through eustachian tube obstruction leading to middle ear effusion with evidence of organization of the inflammatory effusion within 3 months. Organized effusion in the presence of inflammation and mucosal epithelial lining breaks was considered a potential source for granulation tissue formation and CG.…”
mentioning
confidence: 99%
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