Experimental Evidence for Therapeutic Potentials of Propolis

Bhargava, Priyanshu; Mahanta, Debajit; Kaul, A.; Ishida, Yoshiyuki; Terao, Keiji; Wadhwa, Renu; Kaul, Sunil C.

doi:10.3390/nu13082528

Cited by 34 publications

(37 citation statements)

References 164 publications

(211 reference statements)

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“…Additionally, biological activities could be associated with their chemical composition. However, 90–100% ethanolic extract of BGP is frequently used as a healthy food and is reported to have anti-inflammatory effects [ 37 , 38 ]. IL-33 is critical for eosinophil-mediated allergic inflammation, and it was reported that serum levels of IL-33 are significantly elevated in patients with AR [ 18 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

Betuletol, a Propolis Component, Suppresses IL-33 Gene Expression and Effective against Eosinophilia

Shaha

Islam²,

Tanaka³

et al. 2022

Molecules

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Propolis, a resinous substance produced by honeybees, has been used in folk medicine since ancient times due to its many biological benefits such as antitumor, antioxidant, antimicrobial, anti-inflammatory, and immunomodulatory effects. Propolis contains flavonoids, terpenoids, aromatic aldehydes, and alcohols, which vary with different climate and environmental conditions. In our study, we examined the antiallergic activity of Brazilian green propolis (BGP) and isolated the active compound that can suppress an allergy-sensitive gene, IL-33, expression and eosinophilia. Ethanolic extract of BGP freeze-dried powder was fractionated with several solvent systems, and the active fractions were collected based on activity measurement. The single active compound was found by thin-layer chromatography. Using column chromatography and NMR, the active compound was isolated and identified as 3,5,7-trihydroxy-6,4’-dimethoxyflavone, also known as betuletol. Further, the antiallergic activity of that has been examined in PMA-induced up-regulation of IL-33 gene expression in Swiss 3T3 cells. Our data showed the IL-33 gene suppression both by BGP and the isolated active compound, betuletol. We also found that betuletol suppressed ERK phosphorylation, suggesting it could be effective in suppressing IL-33 mediated eosinophilic chronic inflammation and will provide new insights to develop potent therapeutics against allergic inflammations.

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Section: Discussionmentioning

confidence: 99%

Betuletol, a Propolis Component, Suppresses IL-33 Gene Expression and Effective against Eosinophilia

Shaha

Islam²,

Tanaka³

et al. 2022

Molecules

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“…Ethanol propolis extract (EEP) has remarkable medical benefits, namely, protection against gamma radiation [46,47]. The antioxidative effects of EEP are associated with free radical absorbability [46][47][48]. A study also showed that increasing the amount of EEP inhibits the luminol of H 2 O 2 chemiluminescence in an in vitro way and suggested that its anti-oxidative capacity is due to the high flavonoid substance [49].…”

Section: Discussionmentioning

confidence: 99%

The Potential of Trigona spp. Propolis as an Antioxidant Agent to Reduce Residual Peroxide after Intra-Coronal Bleaching Treatments

et al. 2022

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The present study aimed to determine the effectiveness of Trigona spp. propolis as an antioxidant to reduce residual peroxide after intra-coronal bleaching treatments. Thirty-five maxillary central incisors were divided into seven groups: five samples without antioxidants; sodium ascorbate 10% combined with Tween 80 0.2%; and Trigona spp. propolis 10%. The lengths of the application time were 1 h, 24 h, and 48 h. Each application time consisted of five samples. Root resection followed by artificial discoloration was performed in the samples. Then, intra-coronal bleaching using 35% hydrogen peroxide was applied. After the tooth color changed, the bleaching material was cleared, and this was followed by the applications of sodium ascorbate 10% combined with Tween 80 0.2% and Trigona spp. propolis 10%. The peroxide residue was measured by assessing dissolved oxygen using a titration analysis with either the Winkler or iodometric method. Data were analyzed using the ANOVA test and Tukey’s HSD test. The lowest peroxide residue amount was found with the application of antioxidants for 48 h after the intra-coronal bleaching treatment using 35% hydrogen peroxide. However, there was no significant difference between sodium ascorbate 10% combined with Tween 80 0.2% and Trigona spp. propolis 10% to reduce peroxide residues after the intra-coronal bleaching treatment (p > 0.05). Therefore, these findings indicate that Trigona spp. propolis 10% effectively reduces peroxide residues after intra-coronal bleaching treatments, which can interfere with the bond of the composite to the tooth surface and shorten the wait time for composite restorations after bleaching treatments.

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“…With regard to the chemical and nutritional composition of propolis, the main group of compounds is represented by phenolic components, mainly flavonoids, phenolic acids, lignans, stilbenes, and coumarins (Table S3 of the Supporting Information); other minor components are beeswax, lipid–wax substances, terpenes, resins, balms, and sugars as well as mono- (glucose and fructose) and disaccharides (sucrose), proteins, amino acids, minerals (Ca, Cu, K, Mg, Mn, Na, and Zn), and vitamins (B 1 , B 2 , B 6 , C, and E) that account for a negligible part of propolis composition. ,− …”

Section: Propolismentioning

confidence: 99%

Bee Products: An Emblematic Example of Underutilized Sources of Bioactive Compounds

Giampieri

Quiles

Cianciosi

et al. 2022

J. Agric. Food Chem.

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Beside honey, honeybees (Apis mellifera L.) are able to produce many byproducts, including bee pollen, propolis, bee bread, royal jelly, and beeswax. Even if the medicinal properties of these byproducts have been recognized for thousands of years by the ancient civilizations, in the modern era, they have a limited use, essentially as nutritional supplements or health products. However, these natural products are excellent sources of bioactive compounds, macro-and micronutrients, that, in a synergistic way, confer multiple biological activities to these byproducts, such as, for example, antimicrobial, antioxidant, and anti-inflammatory properties. This work aims to update the chemical and phytochemical composition of bee pollen, propolis, bee bread, royal jelly, and beeswax and to summarize the main effects exerted by these byproducts on human health, from the anticancer and immunemodulatory activities to the antidiabetic, hypolipidemic, hypotensive, and anti-allergic properties.

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Experimental Evidence for Therapeutic Potentials of Propolis

Cited by 34 publications

References 164 publications

Betuletol, a Propolis Component, Suppresses IL-33 Gene Expression and Effective against Eosinophilia

Betuletol, a Propolis Component, Suppresses IL-33 Gene Expression and Effective against Eosinophilia

The Potential of Trigona spp. Propolis as an Antioxidant Agent to Reduce Residual Peroxide after Intra-Coronal Bleaching Treatments

Bee Products: An Emblematic Example of Underutilized Sources of Bioactive Compounds

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