Experimental Evaluation of the Height of a Random Set of Points in a d-Dimensional Cube

Breimer, Eric; Goldberg, Mark; Kolstad, Brian; Magdon‐Ismail, Malik

doi:10.1007/3-540-44808-x_13

Cited by 2 publications

(1 citation statement)

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“…38,39 In clinical pharmacological studies osmotic rectal infusion systems proved to be interesting alternative for intravenous infusion. 40 A higher plasma concentration of salicylic acid was observed with zinc aspirin than that aspirin lysinate and aspirin. These data clearly indicate that aspirin is more rapidly absorbed from zinc aspirin as compared to aspirin lysinate and aspirin.…”

Section: In-vitro Studiesmentioning

confidence: 97%

Pharmacokinetics and Pharmacodynamics Evaluation of Prepared Zinc Aspirin Suppositories

Mohamed

Aly

Abdel‐Rahman

2003

Bulletin of Pharmaceutical Sciences. Assiut

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bioavailabilities were 94, 88.89 and 83.63 for zinc aspirin; aspirin lysinate and aspirin respectively. The peak plasma concentration (C max ) were 54. 5188, 50.271.68 and 48.091.15 ugl -1 for zinc aspirin, aspirin lysinate and aspirin, respectively. There was significant difference in the t max . The area under the plasma concentration-time curve (AUC) values were 148. 932.79, 140.832.3 and 132.493.56 ug.h/ml for zinc aspirin, aspirin lysinate and aspirin, respectively. There were significant differences in the C max , t max and AUC following oral administration. The anti-inflammatory and analgesic studies revealed that zinc aspirin administered rectally or orally was more effective as anti-inflammatory and analgesic. The invivo studies were correlated with the in-vitro release studies of aspirin from the prepared suppositories.Based on the obtained results, the authors recommend the possible use of zinc aspirin as a substitute of aspirin containing products.

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Section: In-vitro Studiesmentioning

confidence: 97%