Experimental Evaluation of the Effects of Zoledronic Acid on Regenerate Bone Formation and Osteoporosis in Mandibular Distraction Osteogenesis

Clinical comparison of patients with osteonecrosis of the jaws, with and without a history of bisphosphonates administration

“…In studies by LITTLE et al and PAMPU et al, bone mineral density and bone mineral content of regenerated tissue were 30-50% greater in the groups treated with zoledronate compared with the control groups. 12,17 Numerous studies have described the beneficial effects of BPs in the treatment of avascular necrosis of the long bones, sclerosing osteomyelitis of the jaws, and cancer cell adhesions in bone matrix. 1,2,13,16,18,24 It is debatable whether a substance with such a favourable influence on bone preservation could simultaneously be responsible for the complete opposite effect.…”

“…1,16 Zoledronate had a beneficial influence on new bone formation during distraction osteogenesis. 12,17 Several reports describe ONJ in patients who were treated for a long time with BPs due to bone metabolic disorders such as Paget's disease or fibrous dysplasia. 5,24 These data raised the question of whether BPs might play a role in ONJ.…”

Influence of bisphosphonates in orthodontic therapy: Systematic review

“…34,35,39,40 However, once again, these results were obtained in animal experimental studies with a short follow-up period and used drugs with very different antiresorptive powers, such as etinodrate 34 or zoledronic acid. 36,40 They 36,40 reported that the main drawback of osteogenic distraction was a decrease in mineral bone density and mineral content, which may lead to the bone adjacent to the pin becoming osteoporotic. In another study 39 with a different administration regime from the one published by Pampu et al, 36,40 alendronate was given in the postoperative period at a relative antiresorptive power of 100-1000 42 ; a higher bone mineral density was found using dual energy X-ray absorptiometry although this cannot be statistically demonstrated by transmission densitometry.…”

“…Two of the selected studies 36,40 addressed the effects of zoledronic acid on mandibular osteogenic distraction. Both reported that a single intraoperative application of bisphosphonate (systemic administration) shortened the consolidation period and favoured bone formation around mandibular gaps.…”

Effect of icariin on bone formation during distraction osteogenesis in the rabbit mandible

“…Interventional methods, such as transplantation of osteoblast-like cells or bone marrow to the distraction site, injection of growth factors or platelet rich plasma and gene therapy have also been applied to accelerate the maturation of the regenerated bone 17,22 . Some noninterventional methods, such as administration of calcitonin, alendronate and zoledronic acid have also shown promising results 15,20 .…”