We evaluate the cross sections for charmed hadron production from proton-proton reactions pp →D 0 pΛ + c and pp →D * 0 pΛ + c using a hadronic Lagrangian. With empirical coupling constants and cutoff parameters in the form factors, sum of their cross sections at center-of-mass energy of 11.5 GeV is about 1 µb and is comparable to measured inclusive cross section for charmed hadron production from proton-proton reactions. The cross section decreases to about 1 nb at 40 MeV above threshold.