Hydrofluorocarbon (HFC) refrigerants are currently being phased down by 85% over the next two decades due to their high global warming potential (GWP). Hydrofluoroolefin (HFO) refrigerants are being commercialized as replacements for HFCs and have significantly lower GWP and zero ozone depletion potential (ODP). A challenge in the transition to HFO refrigerants is compatibility with the existing equipment. One solution is blending HFO and HFC refrigerants to match equipment performance. Several azeotropic refrigerant mixtures, such as R-450A, R-456A, R-515B, and R-516A, have lower GWP and provide similar thermophysical properties to replace HFCs in existing systems. HFO/HFC blends are excellent alternatives that enable the reduction of HFCs while still maintaining the lifespan of existing equipment. Many HFO/HFC refrigerant mixtures are designed to be azeotropic or near-azeotropic so that if the refrigerant leaks from the system, only a minimal change in composition will occur, which makes servicing the equipment easier. However, this poses a challenge when recycling the refrigerant because conventional distillation cannot be used to separate the HFO/HFC components back into pure products. A proposed solution for separating azeotropic mixtures uses extractive distillation with an ionic liquid (IL) as the entrainer. This novel method offers an efficient means of separating azeotropic refrigerant mixtures. The efficacy of ILs as entrainers is contingent upon their selectivity and strong affinity toward one or more components of the mixture. In addition, the limited availability of solubility data for HFOs and HFCs in ILs constrains the process of selection. This work has identified phosphonium-and imidazolium-based ILs for the separation of four commercial HFO/HFC refrigerant mixtures based on ASPEN Plus simulations.